Type III photosensitization: Attempt for quantification and a way to new sensitizers

Tamas Kriska, Judit Jakus, Agnes Keszler, Rozalia Vanyur, Andras Nemeth, Dezso Gal

Research output: Contribution to journalConference article

7 Citations (Scopus)

Abstract

Earlier results studying the effect of excited triplet photosensitizer on the zymosan-stimulated and luminol-dependent chemiluminescence of macrophages have been quantitatively re-evaluated and rate constant data indicate that the effect is due to triplet-doublet interactions between sensitizer and free radicals generated. Such interactions, named Type III mechanism, compete with Type I and Type II mechanisms depending on the experimental environment. This suggestion resulted in the synthesis of new sensitizers being the first members of the Antioxidant Carrier Sensitizer (ACS) group of molecules. According to preliminary experiments the PDT treatment of tumor bearing mice seems promising with two of such compounds which demonstrate an inhibitory effect in chemical systems already in their ground state.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3563
Publication statusPublished - Jan 1 1999
EventProceedings of the 1998 Photochemotherapy of Cancer and Other Diseases - Stockholm, SWE
Duration: Sep 9 1998Sep 11 1998

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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