Type III photosensitization: Attempt for quantification and a way to new sensitizers

Tamas Kriska, J. Jakus, Agnes Keszler, Rozalia Vanyur, Andras Nemeth, Dezso Gal

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Earlier results studying the effect of excited triplet photosensitizer on the zymosan-stimulated and luminol-dependent chemiluminescence of macrophages have been quantitatively re-evaluated and rate constant data indicate that the effect is due to triplet-doublet interactions between sensitizer and free radicals generated. Such interactions, named Type III mechanism, compete with Type I and Type II mechanisms depending on the experimental environment. This suggestion resulted in the synthesis of new sensitizers being the first members of the Antioxidant Carrier Sensitizer (ACS) group of molecules. According to preliminary experiments the PDT treatment of tumor bearing mice seems promising with two of such compounds which demonstrate an inhibitory effect in chemical systems already in their ground state.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages11-17
Number of pages7
Volume3563
Publication statusPublished - 1999
EventProceedings of the 1998 Photochemotherapy of Cancer and Other Diseases - Stockholm, SWE
Duration: Sep 9 1998Sep 11 1998

Other

OtherProceedings of the 1998 Photochemotherapy of Cancer and Other Diseases
CityStockholm, SWE
Period9/9/989/11/98

Fingerprint

Bearings (structural)
Photosensitizers
Chemiluminescence
Macrophages
Antioxidants
Free radicals
Ground state
Tumors
Rate constants
Molecules
macrophages
Experiments
chemiluminescence
antioxidants
free radicals
suggestion
mice
tumors
interactions
ground state

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kriska, T., Jakus, J., Keszler, A., Vanyur, R., Nemeth, A., & Gal, D. (1999). Type III photosensitization: Attempt for quantification and a way to new sensitizers. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3563, pp. 11-17). Society of Photo-Optical Instrumentation Engineers.

Type III photosensitization : Attempt for quantification and a way to new sensitizers. / Kriska, Tamas; Jakus, J.; Keszler, Agnes; Vanyur, Rozalia; Nemeth, Andras; Gal, Dezso.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3563 Society of Photo-Optical Instrumentation Engineers, 1999. p. 11-17.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kriska, T, Jakus, J, Keszler, A, Vanyur, R, Nemeth, A & Gal, D 1999, Type III photosensitization: Attempt for quantification and a way to new sensitizers. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3563, Society of Photo-Optical Instrumentation Engineers, pp. 11-17, Proceedings of the 1998 Photochemotherapy of Cancer and Other Diseases, Stockholm, SWE, 9/9/98.
Kriska T, Jakus J, Keszler A, Vanyur R, Nemeth A, Gal D. Type III photosensitization: Attempt for quantification and a way to new sensitizers. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3563. Society of Photo-Optical Instrumentation Engineers. 1999. p. 11-17
Kriska, Tamas ; Jakus, J. ; Keszler, Agnes ; Vanyur, Rozalia ; Nemeth, Andras ; Gal, Dezso. / Type III photosensitization : Attempt for quantification and a way to new sensitizers. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3563 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 11-17
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