Type 1 diabetes associated with Hashimoto's thyroiditis and juvenile rheumatoid arthritis

A case report with clinical and genetic investigations

Katalin H. Nagy, Krisztina Lukacs, Peter Sipos, Robert Hermann, L. Madácsy, G. Soltész

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Autoimmune diseases are initiated by interaction between genetic and environmental factors and caused by the loss of immunologic tolerance to self-antigens. They cluster within families and individuals, but the aggregation in a triad is quite rare. We report a case of a young girl affected by three organ-specific autoimmune disorders, from which type 1 diabetes developed first, then Hashimoto's thyroiditis and juvenile rheumatoid arthritis were diagnosed. Hitherto unreported detailed genetic studies included genotyping of HLA class II, CTLA4, and PTPN22 gene regions. These genes have been associated with autoimmunity in general and some of their variants confer increased risk to all three diseases. Our results - with the limitation of reporting only on a single patient - contribute to the complex genetic background of these clustering organ-specific autoimmune diseases and the analysis of further similar cases might help to reveal how the major and minor genetic factors determine the individual clinical phenotype.

Original languageEnglish
Pages (from-to)579-582
Number of pages4
JournalPediatric Diabetes
Volume11
Issue number8
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Hashimoto Disease
Juvenile Arthritis
Type 1 Diabetes Mellitus
Autoimmune Diseases
Autoantigens
Autoimmunity
Genes
Cluster Analysis
Phenotype
Genetic Background

Keywords

  • Autoimmunity
  • Disease clustering
  • Etiological pathways
  • Genetic factors
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Type 1 diabetes associated with Hashimoto's thyroiditis and juvenile rheumatoid arthritis : A case report with clinical and genetic investigations. / Nagy, Katalin H.; Lukacs, Krisztina; Sipos, Peter; Hermann, Robert; Madácsy, L.; Soltész, G.

In: Pediatric Diabetes, Vol. 11, No. 8, 12.2010, p. 579-582.

Research output: Contribution to journalArticle

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