TxA2-PGI2-PGF(2 alfa) responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension

B. Székács, I. Juhasz, B. Gachalyi, J. Fehér

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In blood pressure (BP) reduction induced by gallopamil, hydralazine and prazosin in patients with essential hypertension a common trend was found in renal prostanoid production which included increased TxB2 excretion and/or augmented TxB2/6-keto-PGF(1alfa) ratio and, with the exception of response to prazosin, enhanced PGF(2alfa) excretion. Role of direct biochemical actions by the drugs in these responses was excluded by in vitro experiments with kidney slices from rats. The clinical and in vitro experimental findings suggested a mediator role of sympathetic activation but not that of the increased renin release in the urinary eicosanoid responses. Significant correlation was observed between the changes in reabsorbed amounts of sodium and excreted amounts of TxB2 and PGF(2alfa). The results suggest that the reactivity of pressure type prostanoids in the kidney could be considered as part of a more complex renal counteraction to BP decrease.

Original languageEnglish
Pages (from-to)395-408
Number of pages14
JournalActa Physiologica Hungarica
Volume81
Issue number4
Publication statusPublished - 1993

Fingerprint

Prostaglandins F
Epoprostenol
Vasodilator Agents
Blood Pressure
Kidney
Prazosin
Prostaglandins
Gallopamil
Hydralazine
Eicosanoids
Renin
Sodium
Pressure
Essential Hypertension
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • essential hypertension
  • gallopamil
  • hydralazine
  • plasma renin activity
  • prazosin
  • renal counterregulation
  • sodium reabsorption
  • urinary renal prostanoids

ASJC Scopus subject areas

  • Physiology

Cite this

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title = "TxA2-PGI2-PGF(2 alfa) responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension",
abstract = "In blood pressure (BP) reduction induced by gallopamil, hydralazine and prazosin in patients with essential hypertension a common trend was found in renal prostanoid production which included increased TxB2 excretion and/or augmented TxB2/6-keto-PGF(1alfa) ratio and, with the exception of response to prazosin, enhanced PGF(2alfa) excretion. Role of direct biochemical actions by the drugs in these responses was excluded by in vitro experiments with kidney slices from rats. The clinical and in vitro experimental findings suggested a mediator role of sympathetic activation but not that of the increased renin release in the urinary eicosanoid responses. Significant correlation was observed between the changes in reabsorbed amounts of sodium and excreted amounts of TxB2 and PGF(2alfa). The results suggest that the reactivity of pressure type prostanoids in the kidney could be considered as part of a more complex renal counteraction to BP decrease.",
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author = "B. Sz{\'e}k{\'a}cs and I. Juhasz and B. Gachalyi and J. Feh{\'e}r",
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T1 - TxA2-PGI2-PGF(2 alfa) responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension

AU - Székács, B.

AU - Juhasz, I.

AU - Gachalyi, B.

AU - Fehér, J.

PY - 1993

Y1 - 1993

N2 - In blood pressure (BP) reduction induced by gallopamil, hydralazine and prazosin in patients with essential hypertension a common trend was found in renal prostanoid production which included increased TxB2 excretion and/or augmented TxB2/6-keto-PGF(1alfa) ratio and, with the exception of response to prazosin, enhanced PGF(2alfa) excretion. Role of direct biochemical actions by the drugs in these responses was excluded by in vitro experiments with kidney slices from rats. The clinical and in vitro experimental findings suggested a mediator role of sympathetic activation but not that of the increased renin release in the urinary eicosanoid responses. Significant correlation was observed between the changes in reabsorbed amounts of sodium and excreted amounts of TxB2 and PGF(2alfa). The results suggest that the reactivity of pressure type prostanoids in the kidney could be considered as part of a more complex renal counteraction to BP decrease.

AB - In blood pressure (BP) reduction induced by gallopamil, hydralazine and prazosin in patients with essential hypertension a common trend was found in renal prostanoid production which included increased TxB2 excretion and/or augmented TxB2/6-keto-PGF(1alfa) ratio and, with the exception of response to prazosin, enhanced PGF(2alfa) excretion. Role of direct biochemical actions by the drugs in these responses was excluded by in vitro experiments with kidney slices from rats. The clinical and in vitro experimental findings suggested a mediator role of sympathetic activation but not that of the increased renin release in the urinary eicosanoid responses. Significant correlation was observed between the changes in reabsorbed amounts of sodium and excreted amounts of TxB2 and PGF(2alfa). The results suggest that the reactivity of pressure type prostanoids in the kidney could be considered as part of a more complex renal counteraction to BP decrease.

KW - essential hypertension

KW - gallopamil

KW - hydralazine

KW - plasma renin activity

KW - prazosin

KW - renal counterregulation

KW - sodium reabsorption

KW - urinary renal prostanoids

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