TxA2-PGI2-PGF(2 alfa) responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension

B. Szekacs, I. Juhasz, B. Gachalyi, J. Feher

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In blood pressure (BP) reduction induced by gallopamil, hydralazine and prazosin in patients with essential hypertension a common trend was found in renal prostanoid production which included increased TxB2 excretion and/or augmented TxB2/6-keto-PGF(1alfa) ratio and, with the exception of response to prazosin, enhanced PGF(2alfa) excretion. Role of direct biochemical actions by the drugs in these responses was excluded by in vitro experiments with kidney slices from rats. The clinical and in vitro experimental findings suggested a mediator role of sympathetic activation but not that of the increased renin release in the urinary eicosanoid responses. Significant correlation was observed between the changes in reabsorbed amounts of sodium and excreted amounts of TxB2 and PGF(2alfa). The results suggest that the reactivity of pressure type prostanoids in the kidney could be considered as part of a more complex renal counteraction to BP decrease.

Original languageEnglish
Pages (from-to)395-408
Number of pages14
JournalActa physiologica Hungarica
Volume81
Issue number4
Publication statusPublished - Dec 1 1993

Keywords

  • essential hypertension
  • gallopamil
  • hydralazine
  • plasma renin activity
  • prazosin
  • renal counterregulation
  • sodium reabsorption
  • urinary renal prostanoids

ASJC Scopus subject areas

  • Physiology (medical)

Fingerprint Dive into the research topics of 'TxA<sub>2</sub>-PGI<sub>2</sub>-PGF(2 alfa) responses in the kidney to blood pressure reduction induced by vasodilator/vasorelaxing agents with different action in patients with essential hypertension'. Together they form a unique fingerprint.

  • Cite this