Two successful pregnancies following eight miscarriages in a patient with antithrombin deficiency

A. Szilágyi, Á Nagy, P. Tamás, M. Vizer, I. Szabó, H. Losonczy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Inherited thrombophilias are associated with an increased risk of maternal thromboembolism and certain adverse pregnancy outcomes, including second- and third-trimester fetal loss, placental abruption, severe intrauterine growth restriction, and early-onset, severe preeclampsia. Pregnant patients with severe thrombophilias, especially antithrombinopathies are at very high risk for both thromboembolism and adverse pregnancy outcomes. A case of a patient with antithrombin deficiency is reported, who had two successful pregnancies after eight miscarriages. Our case shows that a combined treatment with antithrombin substitution and a prophylactic, body-weight-adjusted dose of low-molecular-weight heparin may be successful in preventing pregnancy loss and thromboembolism in antithrombin deficiency during pregnancy, although other complications, such as preeclampsia and intrauterine growth restriction cannot always be prevented.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume61
Issue number2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

Antithrombins
Thromboembolism
Spontaneous Abortion
Pregnancy Outcome
Pre-Eclampsia
Pregnancy
Abruptio Placentae
Low Molecular Weight Heparin
Third Pregnancy Trimester
Second Pregnancy Trimester
Growth
Body Weight
Mothers
Therapeutics

Keywords

  • Antithrombin deficiency
  • Repeated pregnancy loss

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Two successful pregnancies following eight miscarriages in a patient with antithrombin deficiency. / Szilágyi, A.; Nagy, Á; Tamás, P.; Vizer, M.; Szabó, I.; Losonczy, H.

In: Gynecologic and Obstetric Investigation, Vol. 61, No. 2, 02.2006, p. 111-114.

Research output: Contribution to journalArticle

Szilágyi, A. ; Nagy, Á ; Tamás, P. ; Vizer, M. ; Szabó, I. ; Losonczy, H. / Two successful pregnancies following eight miscarriages in a patient with antithrombin deficiency. In: Gynecologic and Obstetric Investigation. 2006 ; Vol. 61, No. 2. pp. 111-114.
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