Two subgroups of stapes fixation: Otosclerosis and pseudo-otosclerosis

T. Karosi, József Kónya, M. Petkó, László Z. Szabó, József Pytel, J. Jóri, I. Sziklai

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

HYPOTHESIS: Stapes ankylosis is a disease with variable histopathology and can be caused by otosclerosis or pseudo-otosclerosis. Viral pathogenesis of otosclerosis could be established only by correlative analysis: histologic examination of the stapes footplate and reverse-transcriptase polymerase chain reaction (RT-PCR) amplification of the viral RNA. BACKGROUND: Presence of the RNA genome of measles virus was demonstrated in the footplates of clinically otosclerotic patients by RT-PCR, and also viral proteins were detected by immunohistochemistry. METHODS: Nucleic acids were extracted from ankylotic stapes footplates of clinically stapes fixation patients (n = 104). Measles virus genomic nucleoprotein (NP) RNA was amplified by seminested RT-PCR. Amplification results were correlated to postoperative histologic and audiologic findings. RESULTS: Measles virus RNA was detectable only in histologically otosclerotic stapes footplates (n = 67). Histology for virus negative footplates (n = 37) excluded otosclerosis. Virus negative stapes footplates showed nonotosclerotic, degenerative disorders. CONCLUSIONS: Stapes ankylosis is a heterogeneous disease causing conductive hearing loss with different etiologies. Nonotosclerotic stapes fixations could be established as pseudo-otosclerosis and may belong to nonspecific, degenerative disorders with variable and noncharacteristic histopathology. Otosclerosis is an inflammatory disease caused by persisting measles virus infection of the otic cap-sule.

Original languageEnglish
Pages (from-to)1968-1973
Number of pages6
JournalLaryngoscope
Volume115
Issue number11
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Stapes
Otosclerosis
Measles virus
Reverse Transcriptase Polymerase Chain Reaction
Ankylosis
RNA
Viruses
Conductive Hearing Loss
Viral RNA
Viral Proteins
Virus Diseases
Nucleic Acids
Ear
Histology
Immunohistochemistry
Genome

Keywords

  • Measles virus
  • Otosclerosis
  • Pseudo-otosclerosis
  • Stapes ankylosis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Two subgroups of stapes fixation : Otosclerosis and pseudo-otosclerosis. / Karosi, T.; Kónya, József; Petkó, M.; Szabó, László Z.; Pytel, József; Jóri, J.; Sziklai, I.

In: Laryngoscope, Vol. 115, No. 11, 11.2005, p. 1968-1973.

Research output: Contribution to journalArticle

Karosi, T. ; Kónya, József ; Petkó, M. ; Szabó, László Z. ; Pytel, József ; Jóri, J. ; Sziklai, I. / Two subgroups of stapes fixation : Otosclerosis and pseudo-otosclerosis. In: Laryngoscope. 2005 ; Vol. 115, No. 11. pp. 1968-1973.
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AB - HYPOTHESIS: Stapes ankylosis is a disease with variable histopathology and can be caused by otosclerosis or pseudo-otosclerosis. Viral pathogenesis of otosclerosis could be established only by correlative analysis: histologic examination of the stapes footplate and reverse-transcriptase polymerase chain reaction (RT-PCR) amplification of the viral RNA. BACKGROUND: Presence of the RNA genome of measles virus was demonstrated in the footplates of clinically otosclerotic patients by RT-PCR, and also viral proteins were detected by immunohistochemistry. METHODS: Nucleic acids were extracted from ankylotic stapes footplates of clinically stapes fixation patients (n = 104). Measles virus genomic nucleoprotein (NP) RNA was amplified by seminested RT-PCR. Amplification results were correlated to postoperative histologic and audiologic findings. RESULTS: Measles virus RNA was detectable only in histologically otosclerotic stapes footplates (n = 67). Histology for virus negative footplates (n = 37) excluded otosclerosis. Virus negative stapes footplates showed nonotosclerotic, degenerative disorders. CONCLUSIONS: Stapes ankylosis is a heterogeneous disease causing conductive hearing loss with different etiologies. Nonotosclerotic stapes fixations could be established as pseudo-otosclerosis and may belong to nonspecific, degenerative disorders with variable and noncharacteristic histopathology. Otosclerosis is an inflammatory disease caused by persisting measles virus infection of the otic cap-sule.

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