Two separate synchronizing mechanisms in the basal forebrain: Study of the synchronizing effects of the rostral hypothalamus, preoptic region and olfactory tubercle

G. Benedek, F. Obal, L. Szekeres, F. Obal

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Systematic mapping of the region between the rostral hypothalamus and the olfactory tubercle by means of low and high frequency stimulations revealed a dorsal and ventral synchronizing area having diverse functional characteristics. The ventral region included the laterobasal preoptic area and the cortical part of the olfactory tubercle. Although differences were found in the type of synchronization elicited by low frequency stimulation of the two areas, the cortical and hippocampal synchronizing effect of high frequency stimulation showed a common feature. The dorsal region extended from the lateral hypothalamus through the dorsal preoptic area to the olfactory tubercle. Its characteristics were similar to those of the nonspecific thalamic system, i.e., low frequency stimulations resulted in recruiting type cortical synchronization, while high frequency stimulations desynchronized cortical and hippocampal activity. The regions in the vicinity of the midline were of a powerful desynchronizing nature. High frequency stimulation resulted in cortical desynchronization as well as hippocampal theta activity, and sometimes cortical desynchronization was induced even by low frequency stimulation. This activity was accompanied by high voltage hippocampal synchronization. It is suggested that direct cortical pathways to the ventral synchronizing area and the participation of the thalamus in producing the synchronizing effect of the dorsal area are the cause of the diverse activities associated with these two regions. Pathways from the dorsal area to the brain stem reticular formation may be responsible for the desynchronization obtained by high frequency stimulation of the dorsal area.

Original languageEnglish
Pages (from-to)164-185
Number of pages22
JournalArchives Italiennes de Biologie
Volume117
Issue number2
Publication statusPublished - Dec 1 1979

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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