Two new methods to form substituted oligoethylene glycols

Krzysztof E. Krakowiak, Jerald S. Bradshaw, P. Huszthy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1-Bromo-2-trityloxyethane (1) and 1-allyloxymethyl-2-trityloxyethanol (2) react readily at room temperature with substituted oligoethylene glycols or the ditosylate derivative of an oligoethylene glycol, respectively, to form the extended, ditrityl-protected, substituted oligoethylene glycols in high yields. The trityl groups are easily removed by acidified methanol in CH2Cl2 to give the extended, substituted oligoethylene glycols.

Original languageEnglish
Pages (from-to)2853-2856
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number18
DOIs
Publication statusPublished - May 2 1994

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Glycols
Methanol
Derivatives
Temperature

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Two new methods to form substituted oligoethylene glycols. / Krakowiak, Krzysztof E.; Bradshaw, Jerald S.; Huszthy, P.

In: Tetrahedron Letters, Vol. 35, No. 18, 02.05.1994, p. 2853-2856.

Research output: Contribution to journalArticle

Krakowiak, Krzysztof E. ; Bradshaw, Jerald S. ; Huszthy, P. / Two new methods to form substituted oligoethylene glycols. In: Tetrahedron Letters. 1994 ; Vol. 35, No. 18. pp. 2853-2856.
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