Two new fusidilactones from the fungal endophyte Fusidium sp

Song Qin, Karsten Krohn, Ulrich Flörke, Barbara Schulz, Siegfried Draeger, Gennaro Pescitelli, Piero Salvadori, Sándor Antus, Tibor Kurtán

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The new bicyclic fusidilactones D (1) and E (2), along with the known and related fusidilactone B (3), have been isolated from the fungal endophyte Fusidium sp. The structures of the new compounds were elucidated by detailed spectroscopic analysis and the relative configurations were confirmed by an X-ray diffraction study of a single crystal of 3. The absolute configurations were determined by TDDFT calculations of CD spectra using the solid-state CD/TDDFT approach. The metabolites exhibited moderate antifungal, antibacterial, and antialgal activities.

Original languageEnglish
Pages (from-to)3279-3284
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number19
DOIs
Publication statusPublished - Jul 1 2009

Keywords

  • Biological activity
  • Configuration determination
  • Density functional calculations
  • Endophytic fungi
  • Fusidilactones
  • Natural products

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Qin, S., Krohn, K., Flörke, U., Schulz, B., Draeger, S., Pescitelli, G., Salvadori, P., Antus, S., & Kurtán, T. (2009). Two new fusidilactones from the fungal endophyte Fusidium sp. European Journal of Organic Chemistry, (19), 3279-3284. https://doi.org/10.1002/ejoc.200900152