Two new fusidilactones from the fungal endophyte Fusidium sp

Song Qin, Karsten Krohn, Ulrich Flörke, Barbara Schulz, Siegfried Draeger, Gennaro Pescitelli, Piero Salvadori, S. Antus, T. Kurtán

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The new bicyclic fusidilactones D (1) and E (2), along with the known and related fusidilactone B (3), have been isolated from the fungal endophyte Fusidium sp. The structures of the new compounds were elucidated by detailed spectroscopic analysis and the relative configurations were confirmed by an X-ray diffraction study of a single crystal of 3. The absolute configurations were determined by TDDFT calculations of CD spectra using the solid-state CD/TDDFT approach. The metabolites exhibited moderate antifungal, antibacterial, and antialgal activities.

Original languageEnglish
Pages (from-to)3279-3284
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number19
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Endophytes
Spectroscopic analysis
Metabolites
X-Ray Diffraction
Single crystals
X ray diffraction
metabolites
spectroscopic analysis
configurations
solid state
single crystals
diffraction
x rays
fusidilactone B

Keywords

  • Biological activity
  • Configuration determination
  • Density functional calculations
  • Endophytic fungi
  • Fusidilactones
  • Natural products

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Qin, S., Krohn, K., Flörke, U., Schulz, B., Draeger, S., Pescitelli, G., ... Kurtán, T. (2009). Two new fusidilactones from the fungal endophyte Fusidium sp. European Journal of Organic Chemistry, (19), 3279-3284. https://doi.org/10.1002/ejoc.200900152

Two new fusidilactones from the fungal endophyte Fusidium sp. / Qin, Song; Krohn, Karsten; Flörke, Ulrich; Schulz, Barbara; Draeger, Siegfried; Pescitelli, Gennaro; Salvadori, Piero; Antus, S.; Kurtán, T.

In: European Journal of Organic Chemistry, No. 19, 07.2009, p. 3279-3284.

Research output: Contribution to journalArticle

Qin, S, Krohn, K, Flörke, U, Schulz, B, Draeger, S, Pescitelli, G, Salvadori, P, Antus, S & Kurtán, T 2009, 'Two new fusidilactones from the fungal endophyte Fusidium sp', European Journal of Organic Chemistry, no. 19, pp. 3279-3284. https://doi.org/10.1002/ejoc.200900152
Qin S, Krohn K, Flörke U, Schulz B, Draeger S, Pescitelli G et al. Two new fusidilactones from the fungal endophyte Fusidium sp. European Journal of Organic Chemistry. 2009 Jul;(19):3279-3284. https://doi.org/10.1002/ejoc.200900152
Qin, Song ; Krohn, Karsten ; Flörke, Ulrich ; Schulz, Barbara ; Draeger, Siegfried ; Pescitelli, Gennaro ; Salvadori, Piero ; Antus, S. ; Kurtán, T. / Two new fusidilactones from the fungal endophyte Fusidium sp. In: European Journal of Organic Chemistry. 2009 ; No. 19. pp. 3279-3284.
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