Two kinds of opiate receptor

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Studies with azidomorphine derivatives have revealed that some of them, particularly N-cyclopropylmethylnorazidomorphine (CAM), stimulate some opiate receptors, while inhibiting the others. The opiate receptors stimulated by CAM are called opiate A receptors, while those antagonized by CAM are called opiate B receptors. Opiate receptors are located at nerve terminals and upon stimulation decrease the release of a neurotransmitter. Opiate A receptors are most probably located at cholinergic nerve terminals, are present in the guinea pig ileum, mouse vas deferens and in the brain. Their stimulation leads to constipation and mental clouding. Opiate B receptors located on adrenergic nerve terminals are present in the cat nictitating membrane and in the brain. Their stimulation produces analgesia, depression of coughing and respiration, catalepsy, and mental clouding.

Original languageEnglish
Pages (from-to)165-175
Number of pages11
JournalPolish Journal of Pharmacology and Pharmacy
Volume29
Issue number3
Publication statusPublished - 1977

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Opioid Receptors
Nictitating Membrane
Catalepsy
Vas Deferens
Brain
Constipation
Ileum
Adrenergic Agents
Analgesia
Cholinergic Agents
Neurotransmitter Agents
Respiration
Guinea Pigs
Cats
N-cyclopropylmethylnorazidomorphine

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Two kinds of opiate receptor. / Knoll, J.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 29, No. 3, 1977, p. 165-175.

Research output: Contribution to journalArticle

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