Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions

R. L. Katona, P. Loyer, Sarah K. Roby, Jill M. Lahti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cyclin C is a highly conserved protein that is involved in divergent cellular processes. The exact roles of its isoforms are presently not very well defined and it is possible that there is a functional divergence amongst them. We therefore sought to assess the expression pattern of cyclin C1 and C2 isoforms in various human tissues and in cell cycle by using real-time PCR experiments. Our findings strongly suggest that the C2 isoform may play a presently unexplored and important role in mammalian testis and probably this isoform is the one that is mainly implicated in cell cycle regulation.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalActa biologica Hungarica
Volume58
Issue number1
DOIs
Publication statusPublished - Mar 1 2007

Keywords

  • Cell cycle
  • Cyclin C
  • Isoforms
  • Real-time PCR
  • Transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Fingerprint Dive into the research topics of 'Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions'. Together they form a unique fingerprint.

  • Cite this