Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary - the rising trend continues (or peaks and highlands?)

Eva Krisztina Gyurus, Chris Patterson, G. Soltész, Acsai László, Almássy Zsuzsa, Balogh Márta, Barkai László, Bátori Bea, Békefi Dezso, Blatniczky László, Bökönyi Zsuzsa, Buzogány Mária, Csákváry Violetta, Cser Ágnes, Dósa Magdolna, Drexler Miklós, Balázsik Andrea, E. Erhardt, Fekete Gréta Anna, Felszeghy Eniko & 47 others Gál Veronika, Gajzer Éva, Gelencsér Éva, Godó Béla, Góg Erzsébet, Gyürüs Éva, Hosszú Éva, Jány Anna, H. Nagy Katalin, Hocsi Mária, Károlyi György, Karádi Zsuzsa, Kántor Irén, Kánitz Edit, Kersák János, Keszei Károly, Kocsis Katalin, Kozári Adrienne, Korányi Judit, A. Körner, Kürti Kálmán, Lovászi Éva, Luczai Andrea, L. Madácsy, Maróti Ágnes, Molnár Mária, Némedi Mária, Niederland Tamás, Petheö István, Ragó Mária, Retkes Tamás, Rippl Ilona, Román Ferenc, Sípos Edit, Soltész Gyula, Soós Andrea, Soós Hajnalka, Sólyom Zsolt, Somlai Rozália, Szabó Ildikó, Szabó László, Szuts Péter, Tihanyi Margit, Torday Judit, Tóth Péter, Tóth Tamás, Ulveczky Erzsébet

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0-14 yr in Hungary over the period 1989-2009. Newly diagnosed children with type 1 diabetes aged 0-14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective registration using hospital notifications. Case ascertainment was over 96% complete using the capture-recapture method. Standardized incidence rates were calculated and secular trends estimated using Poisson regression analysis. In Hungary during 1989-2009 a total number of 3432 children were identified, giving a standardized incidence rate of 12.5 [95% confidence interval (CI) 12.1-12.9] per 100 000 person yr. The overall incidence rate has doubled from 7.7 (95% CI 6.4-9.15) per 100 000 per yr in 1989 to 18.2 (95% CI 15.7-20.9) per 100 000 per yr in 2009. A significant linear trend in incidence (p <0.001) has been observed over time, with a mean annual increase of 4.4%. The increase in incidence was present in both genders and in all age groups, with the largest relative increase in the youngest age group (6.2%; p <0.001). The incidence of type 1 diabetes in Hungarian children continues to increase, with the highest rate in the very young. Although it seems that transient periods of stabilization followed by increases in incidence are apparent, the long-term trend continues to be steadily upward. Incidence of childhood type 1 diabetes is a dynamic process, probably reflecting the changes of the environmental exposures and continued registration is necessary to recognize these trends.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
JournalPediatric Diabetes
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2012

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Hungary
Type 1 Diabetes Mellitus
Incidence
Confidence Intervals
Age Groups
Environmental Exposure
Regression Analysis

Keywords

  • Children
  • Incidence
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary - the rising trend continues (or peaks and highlands?). / Gyurus, Eva Krisztina; Patterson, Chris; Soltész, G.; László, Acsai; Zsuzsa, Almássy; Márta, Balogh; László, Barkai; Bea, Bátori; Dezso, Békefi; László, Blatniczky; Zsuzsa, Bökönyi; Mária, Buzogány; Violetta, Csákváry; Ágnes, Cser; Magdolna, Dósa; Miklós, Drexler; Andrea, Balázsik; Erhardt, E.; Anna, Fekete Gréta; Eniko, Felszeghy; Veronika, Gál; Éva, Gajzer; Éva, Gelencsér; Béla, Godó; Erzsébet, Góg; Éva, Gyürüs; Éva, Hosszú; Anna, Jány; Katalin, H. Nagy; Mária, Hocsi; György, Károlyi; Zsuzsa, Karádi; Irén, Kántor; Edit, Kánitz; János, Kersák; Károly, Keszei; Katalin, Kocsis; Adrienne, Kozári; Judit, Korányi; Körner, A.; Kálmán, Kürti; Éva, Lovászi; Andrea, Luczai; Madácsy, L.; Ágnes, Maróti; Mária, Molnár; Mária, Némedi; Tamás, Niederland; István, Petheö; Mária, Ragó; Tamás, Retkes; Ilona, Rippl; Ferenc, Román; Edit, Sípos; Gyula, Soltész; Andrea, Soós; Hajnalka, Soós; Zsolt, Sólyom; Rozália, Somlai; Ildikó, Szabó; László, Szabó; Péter, Szuts; Margit, Tihanyi; Judit, Torday; Péter, Tóth; Tamás, Tóth; Erzsébet, Ulveczky.

In: Pediatric Diabetes, Vol. 13, No. 1, 02.2012, p. 21-25.

Research output: Contribution to journalArticle

Gyurus, EK, Patterson, C, Soltész, G, László, A, Zsuzsa, A, Márta, B, László, B, Bea, B, Dezso, B, László, B, Zsuzsa, B, Mária, B, Violetta, C, Ágnes, C, Magdolna, D, Miklós, D, Andrea, B, Erhardt, E, Anna, FG, Eniko, F, Veronika, G, Éva, G, Éva, G, Béla, G, Erzsébet, G, Éva, G, Éva, H, Anna, J, Katalin, HN, Mária, H, György, K, Zsuzsa, K, Irén, K, Edit, K, János, K, Károly, K, Katalin, K, Adrienne, K, Judit, K, Körner, A, Kálmán, K, Éva, L, Andrea, L, Madácsy, L, Ágnes, M, Mária, M, Mária, N, Tamás, N, István, P, Mária, R, Tamás, R, Ilona, R, Ferenc, R, Edit, S, Gyula, S, Andrea, S, Hajnalka, S, Zsolt, S, Rozália, S, Ildikó, S, László, S, Péter, S, Margit, T, Judit, T, Péter, T, Tamás, T & Erzsébet, U 2012, 'Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary - the rising trend continues (or peaks and highlands?)', Pediatric Diabetes, vol. 13, no. 1, pp. 21-25. https://doi.org/10.1111/j.1399-5448.2011.00826.x
Gyurus, Eva Krisztina ; Patterson, Chris ; Soltész, G. ; László, Acsai ; Zsuzsa, Almássy ; Márta, Balogh ; László, Barkai ; Bea, Bátori ; Dezso, Békefi ; László, Blatniczky ; Zsuzsa, Bökönyi ; Mária, Buzogány ; Violetta, Csákváry ; Ágnes, Cser ; Magdolna, Dósa ; Miklós, Drexler ; Andrea, Balázsik ; Erhardt, E. ; Anna, Fekete Gréta ; Eniko, Felszeghy ; Veronika, Gál ; Éva, Gajzer ; Éva, Gelencsér ; Béla, Godó ; Erzsébet, Góg ; Éva, Gyürüs ; Éva, Hosszú ; Anna, Jány ; Katalin, H. Nagy ; Mária, Hocsi ; György, Károlyi ; Zsuzsa, Karádi ; Irén, Kántor ; Edit, Kánitz ; János, Kersák ; Károly, Keszei ; Katalin, Kocsis ; Adrienne, Kozári ; Judit, Korányi ; Körner, A. ; Kálmán, Kürti ; Éva, Lovászi ; Andrea, Luczai ; Madácsy, L. ; Ágnes, Maróti ; Mária, Molnár ; Mária, Némedi ; Tamás, Niederland ; István, Petheö ; Mária, Ragó ; Tamás, Retkes ; Ilona, Rippl ; Ferenc, Román ; Edit, Sípos ; Gyula, Soltész ; Andrea, Soós ; Hajnalka, Soós ; Zsolt, Sólyom ; Rozália, Somlai ; Ildikó, Szabó ; László, Szabó ; Péter, Szuts ; Margit, Tihanyi ; Judit, Torday ; Péter, Tóth ; Tamás, Tóth ; Erzsébet, Ulveczky. / Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary - the rising trend continues (or peaks and highlands?). In: Pediatric Diabetes. 2012 ; Vol. 13, No. 1. pp. 21-25.
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TY - JOUR

T1 - Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary - the rising trend continues (or peaks and highlands?)

AU - Gyurus, Eva Krisztina

AU - Patterson, Chris

AU - Soltész, G.

AU - László, Acsai

AU - Zsuzsa, Almássy

AU - Márta, Balogh

AU - László, Barkai

AU - Bea, Bátori

AU - Dezso, Békefi

AU - László, Blatniczky

AU - Zsuzsa, Bökönyi

AU - Mária, Buzogány

AU - Violetta, Csákváry

AU - Ágnes, Cser

AU - Magdolna, Dósa

AU - Miklós, Drexler

AU - Andrea, Balázsik

AU - Erhardt, E.

AU - Anna, Fekete Gréta

AU - Eniko, Felszeghy

AU - Veronika, Gál

AU - Éva, Gajzer

AU - Éva, Gelencsér

AU - Béla, Godó

AU - Erzsébet, Góg

AU - Éva, Gyürüs

AU - Éva, Hosszú

AU - Anna, Jány

AU - Katalin, H. Nagy

AU - Mária, Hocsi

AU - György, Károlyi

AU - Zsuzsa, Karádi

AU - Irén, Kántor

AU - Edit, Kánitz

AU - János, Kersák

AU - Károly, Keszei

AU - Katalin, Kocsis

AU - Adrienne, Kozári

AU - Judit, Korányi

AU - Körner, A.

AU - Kálmán, Kürti

AU - Éva, Lovászi

AU - Andrea, Luczai

AU - Madácsy, L.

AU - Ágnes, Maróti

AU - Mária, Molnár

AU - Mária, Némedi

AU - Tamás, Niederland

AU - István, Petheö

AU - Mária, Ragó

AU - Tamás, Retkes

AU - Ilona, Rippl

AU - Ferenc, Román

AU - Edit, Sípos

AU - Gyula, Soltész

AU - Andrea, Soós

AU - Hajnalka, Soós

AU - Zsolt, Sólyom

AU - Rozália, Somlai

AU - Ildikó, Szabó

AU - László, Szabó

AU - Péter, Szuts

AU - Margit, Tihanyi

AU - Judit, Torday

AU - Péter, Tóth

AU - Tamás, Tóth

AU - Erzsébet, Ulveczky

PY - 2012/2

Y1 - 2012/2

N2 - The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0-14 yr in Hungary over the period 1989-2009. Newly diagnosed children with type 1 diabetes aged 0-14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective registration using hospital notifications. Case ascertainment was over 96% complete using the capture-recapture method. Standardized incidence rates were calculated and secular trends estimated using Poisson regression analysis. In Hungary during 1989-2009 a total number of 3432 children were identified, giving a standardized incidence rate of 12.5 [95% confidence interval (CI) 12.1-12.9] per 100 000 person yr. The overall incidence rate has doubled from 7.7 (95% CI 6.4-9.15) per 100 000 per yr in 1989 to 18.2 (95% CI 15.7-20.9) per 100 000 per yr in 2009. A significant linear trend in incidence (p <0.001) has been observed over time, with a mean annual increase of 4.4%. The increase in incidence was present in both genders and in all age groups, with the largest relative increase in the youngest age group (6.2%; p <0.001). The incidence of type 1 diabetes in Hungarian children continues to increase, with the highest rate in the very young. Although it seems that transient periods of stabilization followed by increases in incidence are apparent, the long-term trend continues to be steadily upward. Incidence of childhood type 1 diabetes is a dynamic process, probably reflecting the changes of the environmental exposures and continued registration is necessary to recognize these trends.

AB - The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0-14 yr in Hungary over the period 1989-2009. Newly diagnosed children with type 1 diabetes aged 0-14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective registration using hospital notifications. Case ascertainment was over 96% complete using the capture-recapture method. Standardized incidence rates were calculated and secular trends estimated using Poisson regression analysis. In Hungary during 1989-2009 a total number of 3432 children were identified, giving a standardized incidence rate of 12.5 [95% confidence interval (CI) 12.1-12.9] per 100 000 person yr. The overall incidence rate has doubled from 7.7 (95% CI 6.4-9.15) per 100 000 per yr in 1989 to 18.2 (95% CI 15.7-20.9) per 100 000 per yr in 2009. A significant linear trend in incidence (p <0.001) has been observed over time, with a mean annual increase of 4.4%. The increase in incidence was present in both genders and in all age groups, with the largest relative increase in the youngest age group (6.2%; p <0.001). The incidence of type 1 diabetes in Hungarian children continues to increase, with the highest rate in the very young. Although it seems that transient periods of stabilization followed by increases in incidence are apparent, the long-term trend continues to be steadily upward. Incidence of childhood type 1 diabetes is a dynamic process, probably reflecting the changes of the environmental exposures and continued registration is necessary to recognize these trends.

KW - Children

KW - Incidence

KW - Type 1 diabetes

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