Turnover and intranuclear localization of 125I-insulin in Tetrahymena. An autoradiographic study.

A. K. Fülöp, G. Csaba

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Abstract

The unicellular Tetrahymena first internalized, then partly released the labelled insulin. Insulin-pretreated (imprinted) Tetrahymena cells behaved differently from non-pretreated cells, in that they retained a greater part of internalized insulin in the cytoplasm. Additional exposure to excessive non-labelled (cold) insulin caused a decrease in intracellular labelled insulin retention. Internalized insulin also entered the nucleus of Tetrahymena, where it was found in a heterochromatic localization.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalActa morphologica Hungarica
Volume39
Issue number2
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Anatomy

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