Turning the tables on surgical oncology: The • Pancho trial unplugged

S. Kappel, C. Bichler, B. Wolf, S. Gacic, S. F. Schoppmann, Y. Devyatko, G. Prager, A. Ba-SSalamah, F. Wrba, U. Pluschnig, I. Kührer, M. Mittlböck, M. Hejna, J. Zacherl, Daniela Kandioler, Johannes Zacherl, Gerhard Prager, Martin Riegler, Irene Kührer, Michael HejnaUrsula Pluschnig, Walter Klepetko, Clemens Aigner, Michael Hold, Marianne Bernhart, Christian Oesterreicher, J. Karner, Sabine Thalhammer, Rudolf Roka, Martin Schermann, Reinhold Függer, Florian Tomaselli, Ronald Zwrtek, Michael Pober, Karl Glaser, Rene Fortelny, Kathrin Strasser-Weippl, Dietmar Öfner, Gilbert Mühlmann, Jörg Tschmelitsch, Harald Weiss, Istvan Viragos-Toth, Friedrich Längle, Nikolaus Hölbling, Felix Keil, Uwe Kastner, Heidrun Wede, Etienne Wenzl, Anton Haid, Michael Knauer, Ahmed Ba-Ssalamah, Martin Uffmann, Martina Mittlböck, Marcus Hudec, Sonja Kappel, Christoph Bichler, Sladjana Gacic, Brigitte Wolf, Fritz Wrba, Martin Klimpfinger, Roland Sedivy, Petra Merz, Daniela Kandioler, Johannes Zacherl, Michael Hejna

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: In esophageal cancer patients neoadjuvant therapy failed to demonstrate a clear benefit in overall survival. A significant advantage can be seen in patients with complete pathological response. Methods: This review summarizes the results of retrospective clinical studies suggesting p53 as a predictive marker for chemotherapy response. To advance these findings to level of evidence I the • Pancho trial was initiated. Results: The • Pancho trial represents the first prospective randomized trial testing the interaction between p53 and response to chemotherapy. The special design of the • Pancho trial (interaction design), the sample size considerations, the study endpoints and the 12 months accrual of this nationwide study are reported. Conclusions: The • Pancho trial evaluates for the first time whether the p53 genotype is qualified to select patients who will respond to certain chemotherapy and to guide cancer therapy.

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalEuropean Surgery - Acta Chirurgica Austriaca
Volume40
Issue number6
DOIs
Publication statusPublished - 2008

Fingerprint

Drug Therapy
Neoadjuvant Therapy
Esophageal Neoplasms
Sample Size
Retrospective Studies
Genotype
Survival
Surgical Oncology
Neoplasms
Therapeutics
Clinical Studies

Keywords

  • Esophageal cancer
  • Individualized cancer therapy
  • Neoadjuvant therapy
  • p53
  • Pancho
  • Predictive marker trial
  • Response prediction

ASJC Scopus subject areas

  • Surgery

Cite this

Kappel, S., Bichler, C., Wolf, B., Gacic, S., Schoppmann, S. F., Devyatko, Y., ... Hejna, M. (2008). Turning the tables on surgical oncology: The • Pancho trial unplugged. European Surgery - Acta Chirurgica Austriaca, 40(6), 277-283. https://doi.org/10.1007/s10353-008-0438-5

Turning the tables on surgical oncology : The • Pancho trial unplugged. / Kappel, S.; Bichler, C.; Wolf, B.; Gacic, S.; Schoppmann, S. F.; Devyatko, Y.; Prager, G.; Ba-SSalamah, A.; Wrba, F.; Pluschnig, U.; Kührer, I.; Mittlböck, M.; Hejna, M.; Zacherl, J.; Kandioler, Daniela; Zacherl, Johannes; Prager, Gerhard; Riegler, Martin; Kührer, Irene; Hejna, Michael; Pluschnig, Ursula; Klepetko, Walter; Aigner, Clemens; Hold, Michael; Bernhart, Marianne; Oesterreicher, Christian; Karner, J.; Thalhammer, Sabine; Roka, Rudolf; Schermann, Martin; Függer, Reinhold; Tomaselli, Florian; Zwrtek, Ronald; Pober, Michael; Glaser, Karl; Fortelny, Rene; Strasser-Weippl, Kathrin; Öfner, Dietmar; Mühlmann, Gilbert; Tschmelitsch, Jörg; Weiss, Harald; Viragos-Toth, Istvan; Längle, Friedrich; Hölbling, Nikolaus; Keil, Felix; Kastner, Uwe; Wede, Heidrun; Wenzl, Etienne; Haid, Anton; Knauer, Michael; Ba-Ssalamah, Ahmed; Uffmann, Martin; Mittlböck, Martina; Hudec, Marcus; Kappel, Sonja; Bichler, Christoph; Gacic, Sladjana; Wolf, Brigitte; Wrba, Fritz; Klimpfinger, Martin; Sedivy, Roland; Merz, Petra; Kandioler, Daniela; Zacherl, Johannes; Hejna, Michael.

In: European Surgery - Acta Chirurgica Austriaca, Vol. 40, No. 6, 2008, p. 277-283.

Research output: Contribution to journalArticle

Kappel, S, Bichler, C, Wolf, B, Gacic, S, Schoppmann, SF, Devyatko, Y, Prager, G, Ba-SSalamah, A, Wrba, F, Pluschnig, U, Kührer, I, Mittlböck, M, Hejna, M, Zacherl, J, Kandioler, D, Zacherl, J, Prager, G, Riegler, M, Kührer, I, Hejna, M, Pluschnig, U, Klepetko, W, Aigner, C, Hold, M, Bernhart, M, Oesterreicher, C, Karner, J, Thalhammer, S, Roka, R, Schermann, M, Függer, R, Tomaselli, F, Zwrtek, R, Pober, M, Glaser, K, Fortelny, R, Strasser-Weippl, K, Öfner, D, Mühlmann, G, Tschmelitsch, J, Weiss, H, Viragos-Toth, I, Längle, F, Hölbling, N, Keil, F, Kastner, U, Wede, H, Wenzl, E, Haid, A, Knauer, M, Ba-Ssalamah, A, Uffmann, M, Mittlböck, M, Hudec, M, Kappel, S, Bichler, C, Gacic, S, Wolf, B, Wrba, F, Klimpfinger, M, Sedivy, R, Merz, P, Kandioler, D, Zacherl, J & Hejna, M 2008, 'Turning the tables on surgical oncology: The • Pancho trial unplugged', European Surgery - Acta Chirurgica Austriaca, vol. 40, no. 6, pp. 277-283. https://doi.org/10.1007/s10353-008-0438-5
Kappel, S. ; Bichler, C. ; Wolf, B. ; Gacic, S. ; Schoppmann, S. F. ; Devyatko, Y. ; Prager, G. ; Ba-SSalamah, A. ; Wrba, F. ; Pluschnig, U. ; Kührer, I. ; Mittlböck, M. ; Hejna, M. ; Zacherl, J. ; Kandioler, Daniela ; Zacherl, Johannes ; Prager, Gerhard ; Riegler, Martin ; Kührer, Irene ; Hejna, Michael ; Pluschnig, Ursula ; Klepetko, Walter ; Aigner, Clemens ; Hold, Michael ; Bernhart, Marianne ; Oesterreicher, Christian ; Karner, J. ; Thalhammer, Sabine ; Roka, Rudolf ; Schermann, Martin ; Függer, Reinhold ; Tomaselli, Florian ; Zwrtek, Ronald ; Pober, Michael ; Glaser, Karl ; Fortelny, Rene ; Strasser-Weippl, Kathrin ; Öfner, Dietmar ; Mühlmann, Gilbert ; Tschmelitsch, Jörg ; Weiss, Harald ; Viragos-Toth, Istvan ; Längle, Friedrich ; Hölbling, Nikolaus ; Keil, Felix ; Kastner, Uwe ; Wede, Heidrun ; Wenzl, Etienne ; Haid, Anton ; Knauer, Michael ; Ba-Ssalamah, Ahmed ; Uffmann, Martin ; Mittlböck, Martina ; Hudec, Marcus ; Kappel, Sonja ; Bichler, Christoph ; Gacic, Sladjana ; Wolf, Brigitte ; Wrba, Fritz ; Klimpfinger, Martin ; Sedivy, Roland ; Merz, Petra ; Kandioler, Daniela ; Zacherl, Johannes ; Hejna, Michael. / Turning the tables on surgical oncology : The • Pancho trial unplugged. In: European Surgery - Acta Chirurgica Austriaca. 2008 ; Vol. 40, No. 6. pp. 277-283.
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AU - Schoppmann, S. F.

AU - Devyatko, Y.

AU - Prager, G.

AU - Ba-SSalamah, A.

AU - Wrba, F.

AU - Pluschnig, U.

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AU - Mittlböck, M.

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AU - Kührer, Irene

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AU - Aigner, Clemens

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AU - Bernhart, Marianne

AU - Oesterreicher, Christian

AU - Karner, J.

AU - Thalhammer, Sabine

AU - Roka, Rudolf

AU - Schermann, Martin

AU - Függer, Reinhold

AU - Tomaselli, Florian

AU - Zwrtek, Ronald

AU - Pober, Michael

AU - Glaser, Karl

AU - Fortelny, Rene

AU - Strasser-Weippl, Kathrin

AU - Öfner, Dietmar

AU - Mühlmann, Gilbert

AU - Tschmelitsch, Jörg

AU - Weiss, Harald

AU - Viragos-Toth, Istvan

AU - Längle, Friedrich

AU - Hölbling, Nikolaus

AU - Keil, Felix

AU - Kastner, Uwe

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AU - Haid, Anton

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AU - Ba-Ssalamah, Ahmed

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AU - Hudec, Marcus

AU - Kappel, Sonja

AU - Bichler, Christoph

AU - Gacic, Sladjana

AU - Wolf, Brigitte

AU - Wrba, Fritz

AU - Klimpfinger, Martin

AU - Sedivy, Roland

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KW - Individualized cancer therapy

KW - Neoadjuvant therapy

KW - p53

KW - Pancho

KW - Predictive marker trial

KW - Response prediction

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