Turning gold into 'junk': Transposable elements utilize central proteins of cellular networks

G. Abrusán, András Szilágyi, Yang Zhang, B. Papp

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The numerous discovered cases of domesticated transposable element (TE) proteins led to the recognition that TEs are a significant source of evolutionary innovation. However, much less is known about the reverse process, whether and to what degree the evolution of TEs is influenced by the genome of their hosts. We addressed this issue by searching for cases of incorporation of host genes into the sequence of TEs and examined the systems-level properties of these genes using the Saccharomyces cerevisiae and Drosophila melanogaster genomes. We identified 51 cases where the evolutionary scenario was the incorporation of a host gene fragment into a TE consensus sequence, and we show that both the yeast and fly homologues of the incorporated protein sequences have central positions in the cellular networks. An analysis of selective pressure (Ka/Ks ratio) detected significant selection in 37% of the cases. Recent research on retrovirus-host interactions shows that virus proteins preferentially target hubs of the host interaction networks enabling them to take over the host cell using only a few proteins. We propose that TEs face a similar evolutionary pressure to evolve proteins with high interacting capacities and take some of the necessary protein domains directly from their hosts.

Original languageEnglish
Pages (from-to)3190-3200
Number of pages11
JournalNucleic Acids Research
Volume41
Issue number5
DOIs
Publication statusPublished - Mar 2013

Fingerprint

DNA Transposable Elements
Gold
Proteins
Genome
Genes
Amino Acid Sequence Homology
Consensus Sequence
Retroviridae
Drosophila melanogaster
Diptera
Saccharomyces cerevisiae
Yeasts
Viruses
Pressure
Research

ASJC Scopus subject areas

  • Genetics

Cite this

Turning gold into 'junk' : Transposable elements utilize central proteins of cellular networks. / Abrusán, G.; Szilágyi, András; Zhang, Yang; Papp, B.

In: Nucleic Acids Research, Vol. 41, No. 5, 03.2013, p. 3190-3200.

Research output: Contribution to journalArticle

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