Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines

Helga Engi, Hiroshi Sakagami, Masami Kawase, Alpesh Parecha, Dinesh Manvar, Himanshu Kothari, Priti Adlaka, Anamik Shah, Noboru Motohashi, I. Ocsovszki, J. Molnár

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The ability of 41 1,4-diphenyl-1,4-dihydropyridine derivatives to inhibit the transport activity of P-glycoprotein were studied by flow cytometry in a multidrug-resistant human colon cancer cell line (COLO320) and in human mdrl gene-transfected mouse lymphoma cells (L 5178 Y). The cytotoxicities of these compounds were also examined against human normal and cancer cell lines. The majority of the tested compounds proved to be effective inhibitors of rhodamine 123 outward transport, but their cytotoxicities were not negligible. Some dihydropyfidine derivatives displayed cytotoxic activity against four human oral tumour cell lines and against three normal human oral cell lines. Mere was no clear-cut relationship between the multidrug-resistance activity or cytotoxicity and the chemical structures of the compounds. New ring substituents could prevent the oxidation of the ring of the aromatic compound.

Original languageEnglish
Pages (from-to)637-644
Number of pages8
JournalIn Vivo
Volume20
Issue number5
Publication statusPublished - Sep 2006

Fingerprint

Dihydropyridines
Cytotoxicity
Tumors
Cells
Neoplasms
Cell Line
Derivatives
Rhodamine 123
Flow cytometry
Aromatic compounds
P-Glycoprotein
Multiple Drug Resistance
Tumor Cell Line
Genes
Colonic Neoplasms
Lymphoma
Flow Cytometry
Oxidation

Keywords

  • Dihydropyridines
  • Efflux pump
  • MDR reversal
  • Multidrug resistance
  • P-glycoprotein
  • Tumour specificity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Engi, H., Sakagami, H., Kawase, M., Parecha, A., Manvar, D., Kothari, H., ... Molnár, J. (2006). Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines. In Vivo, 20(5), 637-644.

Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines. / Engi, Helga; Sakagami, Hiroshi; Kawase, Masami; Parecha, Alpesh; Manvar, Dinesh; Kothari, Himanshu; Adlaka, Priti; Shah, Anamik; Motohashi, Noboru; Ocsovszki, I.; Molnár, J.

In: In Vivo, Vol. 20, No. 5, 09.2006, p. 637-644.

Research output: Contribution to journalArticle

Engi, H, Sakagami, H, Kawase, M, Parecha, A, Manvar, D, Kothari, H, Adlaka, P, Shah, A, Motohashi, N, Ocsovszki, I & Molnár, J 2006, 'Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines', In Vivo, vol. 20, no. 5, pp. 637-644.
Engi H, Sakagami H, Kawase M, Parecha A, Manvar D, Kothari H et al. Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines. In Vivo. 2006 Sep;20(5):637-644.
Engi, Helga ; Sakagami, Hiroshi ; Kawase, Masami ; Parecha, Alpesh ; Manvar, Dinesh ; Kothari, Himanshu ; Adlaka, Priti ; Shah, Anamik ; Motohashi, Noboru ; Ocsovszki, I. ; Molnár, J. / Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines. In: In Vivo. 2006 ; Vol. 20, No. 5. pp. 637-644.
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