Tumour necrosis factor alpha gene (TNF-α) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis

Erika Losonczi, K. Bencsik, Zsanett Fricska Nagy, Viktor Honti, Estilla Szalczer, Cecília Rajda, Zsolt Illés, Klotild Mátyás, C. Rózsa, Tünde Csépány, Judit Füvesi, L. Vécsei

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Tumour necrosis factor alpha (TNF-α) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-α -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p = 0.027; p = 0.032). The G allele may be one of the factors responsible for progression in PPMS.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalJournal of Neuroimmunology
Volume208
Issue number1-2
DOIs
Publication statusPublished - Mar 31 2009

Fingerprint

Chronic Progressive Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Tumor Necrosis Factor-alpha
Alleles
Genes
Guanine
Restriction Fragment Length Polymorphisms
Genotype
Polymerase Chain Reaction
Control Groups

Keywords

  • Multiple sclerosis (MS)
  • Primary progressive multiple sclerosis (PPMS)
  • Single nucleotide polymorphism (SNP)
  • Tumour necrosis factor alpha (TNF-α)

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Tumour necrosis factor alpha gene (TNF-α) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. / Losonczi, Erika; Bencsik, K.; Nagy, Zsanett Fricska; Honti, Viktor; Szalczer, Estilla; Rajda, Cecília; Illés, Zsolt; Mátyás, Klotild; Rózsa, C.; Csépány, Tünde; Füvesi, Judit; Vécsei, L.

In: Journal of Neuroimmunology, Vol. 208, No. 1-2, 31.03.2009, p. 115-118.

Research output: Contribution to journalArticle

Losonczi, Erika ; Bencsik, K. ; Nagy, Zsanett Fricska ; Honti, Viktor ; Szalczer, Estilla ; Rajda, Cecília ; Illés, Zsolt ; Mátyás, Klotild ; Rózsa, C. ; Csépány, Tünde ; Füvesi, Judit ; Vécsei, L. / Tumour necrosis factor alpha gene (TNF-α) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. In: Journal of Neuroimmunology. 2009 ; Vol. 208, No. 1-2. pp. 115-118.
@article{10e9660423ec4b608cd2b306ea0102b0,
title = "Tumour necrosis factor alpha gene (TNF-α) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis",
abstract = "Tumour necrosis factor alpha (TNF-α) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-α -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p = 0.027; p = 0.032). The G allele may be one of the factors responsible for progression in PPMS.",
keywords = "Multiple sclerosis (MS), Primary progressive multiple sclerosis (PPMS), Single nucleotide polymorphism (SNP), Tumour necrosis factor alpha (TNF-α)",
author = "Erika Losonczi and K. Bencsik and Nagy, {Zsanett Fricska} and Viktor Honti and Estilla Szalczer and Cec{\'i}lia Rajda and Zsolt Ill{\'e}s and Klotild M{\'a}ty{\'a}s and C. R{\'o}zsa and T{\"u}nde Cs{\'e}p{\'a}ny and Judit F{\"u}vesi and L. V{\'e}csei",
year = "2009",
month = "3",
day = "31",
doi = "10.1016/j.jneuroim.2009.01.004",
language = "English",
volume = "208",
pages = "115--118",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Tumour necrosis factor alpha gene (TNF-α) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis

AU - Losonczi, Erika

AU - Bencsik, K.

AU - Nagy, Zsanett Fricska

AU - Honti, Viktor

AU - Szalczer, Estilla

AU - Rajda, Cecília

AU - Illés, Zsolt

AU - Mátyás, Klotild

AU - Rózsa, C.

AU - Csépány, Tünde

AU - Füvesi, Judit

AU - Vécsei, L.

PY - 2009/3/31

Y1 - 2009/3/31

N2 - Tumour necrosis factor alpha (TNF-α) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-α -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p = 0.027; p = 0.032). The G allele may be one of the factors responsible for progression in PPMS.

AB - Tumour necrosis factor alpha (TNF-α) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-α -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p = 0.027; p = 0.032). The G allele may be one of the factors responsible for progression in PPMS.

KW - Multiple sclerosis (MS)

KW - Primary progressive multiple sclerosis (PPMS)

KW - Single nucleotide polymorphism (SNP)

KW - Tumour necrosis factor alpha (TNF-α)

UR - http://www.scopus.com/inward/record.url?scp=62549101286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62549101286&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2009.01.004

DO - 10.1016/j.jneuroim.2009.01.004

M3 - Article

C2 - 19201038

AN - SCOPUS:62549101286

VL - 208

SP - 115

EP - 118

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -