Tumour necrosis factor-α and adenosine in endotoxin shock-related cardiovascular symptoms

S. Sipka, T. Seres, Z. Dinya, Z. Szekanecz, J. Szentmiklosi, E. Bodolay, G. Szegedi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-α, and interleukin (IL)-10. We suggest that these cytokines may contribute to the terminal SIRS-related arrythmias, impaired myocardial contractility, as well as increased vascular permeability. In addition, the increased production of adenosine, a counter-regulatory mediator of inflammation, may also play a role in cardiodepression. We suggest a relationship between the action of TNF-α, IL-10 and adenosine in the pathogenesis of circulatory symptoms described above.

Original languageEnglish
Pages (from-to)454-455
Number of pages2
JournalMediators of Inflammation
Volume4
Issue number6
DOIs
Publication statusPublished - 1995

Fingerprint

Systemic Inflammatory Response Syndrome
Endotoxins
Adenosine
Shock
Tumor Necrosis Factor-alpha
Interleukin-10
Inflammation Mediators
Cardiogenic Shock
Capillary Permeability
Cardiac Arrhythmias
Cytokines

Keywords

  • Adenosine
  • Endotoxin shock
  • Factor-α
  • Tumour necrosis

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Tumour necrosis factor-α and adenosine in endotoxin shock-related cardiovascular symptoms. / Sipka, S.; Seres, T.; Dinya, Z.; Szekanecz, Z.; Szentmiklosi, J.; Bodolay, E.; Szegedi, G.

In: Mediators of Inflammation, Vol. 4, No. 6, 1995, p. 454-455.

Research output: Contribution to journalArticle

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AU - Seres, T.

AU - Dinya, Z.

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AU - Szentmiklosi, J.

AU - Bodolay, E.

AU - Szegedi, G.

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