Daganatos megbetegedések rheumatoid arthritisben.

Translated title of the contribution: Tumors in rheumatoid arthritis

M. Bély, A. Apáthy

Research output: Contribution to journalArticle

Abstract

Benign (bTu) and malignant tumours (mTu) were studied in a randomised autopsy material of 161 patients with rheumatoid arthritis (RA). The tissue specimens were fixed in 8% formaldehyde solution at pH 7.6 and embedded in paraffin. The tumours were diagnosed histologically and confirmed by immunohistochemical methods. Five benign (3.1%), and thirteen malignant tumours (8.1%) found observed in 18 (11.2%) of 161 cases. There was no significant difference between laboratory parameters of patients with malignant tumours and without tumours. One benign (0.62%) and seven malignant (4.35%) tumours led to death in 8 (4.97%) of 18 cases altogether. Neoplasms were detected clinically in 8 of 18 cases (44.4 rel%). None of tumorous patients received immunosuppressive treatment and only five had gold (Tauredon) therapy. Paraneoplastic syndromes with rheumatoid complaints may be excluded by the onset and duration of RA and tumours. Benign neurogenic tumours and malignant bronchioloalveolar carcinoma were frequently associated with RA not treated by immunosuppressive drugs. Our data do not support the assumption of a high risk of malignant lymphomas associated with RA treated with immunosuppressive therapy.

Original languageHungarian
Pages (from-to)2567-2574
Number of pages8
JournalOrvosi Hetilap
Volume139
Issue number43
Publication statusPublished - Oct 25 1998

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Rheumatoid Arthritis
Neoplasms
Immunosuppressive Agents
Gold Sodium Thiomalate
Bronchiolo-Alveolar Adenocarcinoma
Paraneoplastic Syndromes
Gold
Paraffin
Formaldehyde
Autopsy
Lymphoma
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Daganatos megbetegedések rheumatoid arthritisben. / Bély, M.; Apáthy, A.

In: Orvosi Hetilap, Vol. 139, No. 43, 25.10.1998, p. 2567-2574.

Research output: Contribution to journalArticle

Bély, M & Apáthy, A 1998, 'Daganatos megbetegedések rheumatoid arthritisben.', Orvosi Hetilap, vol. 139, no. 43, pp. 2567-2574.
Bély, M. ; Apáthy, A. / Daganatos megbetegedések rheumatoid arthritisben. In: Orvosi Hetilap. 1998 ; Vol. 139, No. 43. pp. 2567-2574.
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