Tumorigenic effect of 4-methylphenylhydrazine hydrochloride in Swiss mice

B. Toth, A. Tompa, K. Patil

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

4-Methylphenylhydrazine hydrochloride was administered as 10 weekly subcutaneous injections of 140 μg/g body weight and as 7 weekly intragastric instillations of 250 μg/g body weight in physiological saline to randomly bred Swiss mice. Treatments given subcutaneously resulted in induction of lung tumors in incidences of 36% in females and 44% in males, while intragastric treatment caused a 40% incidence in females. In addition, it gave rise to blood vessel tumors by intragastric route in incidences of 32% in females and 18% in males. In the two physiological saline-treated control groups, the lung tumor incidence (combined) was 20% in females and 21% in males, while the blood vessel tumor incidence (combined) was 7% in females and 6% in males. Histopathologically, the lesions were classified as adenomas and adenocarcinomas of the lungs, and angiomas and angiosarcomas of blood vessels. 4-Methylphenylhydrazine was postulated to be a metabolite of 4-hydroxymethylphenylhydrazine, an ingredient of the commonly eaten mushroom Agaricus bisporus. The implications are discussed with respect to the tumorigenesis data.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalZeitschrift für Krebsforschung und Klinische Onkologie
Volume89
Issue number3
DOIs
Publication statusPublished - Jan 1977

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Vascular Tissue Neoplasms
Incidence
Body Weight
Agaricus
Lung
Hemangiosarcoma
Agaricales
Subcutaneous Injections
Hemangioma
Adenoma
Blood Vessels
Neoplasms
Carcinogenesis
4-methylphenylhydrazine
Control Groups
Therapeutics
Adenocarcinoma of lung

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

Cite this

Tumorigenic effect of 4-methylphenylhydrazine hydrochloride in Swiss mice. / Toth, B.; Tompa, A.; Patil, K.

In: Zeitschrift für Krebsforschung und Klinische Onkologie, Vol. 89, No. 3, 01.1977, p. 245-252.

Research output: Contribution to journalArticle

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