Tumorigenezis: a mintázatfelismerõ receptorok és az autofágia jelátviteli összefüggései

Translated title of the contribution: Tumorigenesis: interplay of pattern recognition receptors and autophagy

Research output: Contribution to journalReview article

Abstract

According to recent data, the involvement of autophagy in tumor development is unquestionable. Nevertheless, cell-derived pathogen/danger-associated molecular pattern (PAMP/DAMP)-sensing Toll-like receptors (TLRs) are also able to contribute to tumorigenesis and immune escape of malignantly transformed cells. Besides immunocompetent cells, several types of tumors also exhibit TLRs. TLR- and autophagy-related signaling pathways, on the other hand, may evolve anti-tumor effects in a context dependent cell- and microenvironment-specific mode. Nowadays, the autophagy machinery has been considered as a crucial homeostatic process of eukaryotic cells, and as essential constituent of the immune system influencing antimicrobial and inflammation-related immune responses. Accumulating evidence indicates that TLRs and autophagy are interdependent in response to PAMPs and DAMPs, in addition there is a bi-directional controling cross-modulation between them. Regarding personalized medicine, theoretically, it is reasonable that manipulation of the TLR-autophagy regulatory loop might be adaptable for anti-cancer therapy.

Original languageHungarian
Pages (from-to)55-63
Number of pages9
JournalMagyar Onkologia
Volume60
Issue number1
Publication statusPublished - Mar 2 2016

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ASJC Scopus subject areas

  • Oncology

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