Tumor surveillance by circulating microRNAs: A hypothesis

Ivan Igaz, Peter Igaz

Research output: Contribution to journalArticle

21 Citations (Scopus)


A growing body of experimental evidence supports the diagnostic relevance of circulating microRNAs in various diseases including cancer. The biological relevance of circulating microRNAs is, however, largely unknown, particularly in healthy individuals. Here, we propose a hypothesis based on the relative abundance of microRNAs with predominant tumor suppressor activity in the blood of healthy individuals. According to our hypothesis, certain sets of circulating microRNAs might function as a tumor surveillance mechanism exerting continuous inhibition on tumor formation. The microRNA-mediated tumor surveillance might complement cancer immune surveillance.

Original languageEnglish
Pages (from-to)4081-4087
Number of pages7
JournalCellular and Molecular Life Sciences
Issue number21
Publication statusPublished - Nov 2014


  • Elimination
  • Microvesicle
  • Nascent tumor
  • Reprogramming

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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