Tumor sinuses - Vascular channels: Facts and fictions

József Tímár, Jeannette Tóth

Research output: Contribution to journalShort survey

26 Citations (Scopus)

Abstract

The existence of tumor cell-lined sinuses (vascular channels) in various experimental and human cancer is known for almost a half a century described by a Hungarian pathologist, Bela Kellner. Meanwhile, even the existence as well as the pathomechanism and the possible functional significance of these sinuses are heavily challenged in the recent literature. Ultrastructural studies however provide evidence for the presence of tumor cell-lined sinuses in human melanoma and breast cancer. The generation of such sinuses can be suggested in two ways: by de novo formation, when tumor cells recapitulate an embryonic geno- and phenotype by reexpressing endothelial genes or by a secondary mechanism, where the incorporated microvessels degenerate due to the predominant expression of anti-angiogenic factors. Literature data are available for the potential diagnostic and clinical significance of the tumor sinuses (vascular channels) stimulating further studies on this issue.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalPathology and Oncology Research
Volume6
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

Keywords

  • Breast cancer
  • Melanoma
  • Pathomechanism
  • Tumor sinus
  • Vascular channel

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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