Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells

I. Andó, G. Hariri, D. Wallace, P. Beverley

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The tumor promoter 12-O-tetradecanoylphorbol 13-acetate induces the expression of the interleukin 2 receptor and the disappearance of the T3 complex in a T cell hybridoma, T cell clones, thymic and peripheral T cells and T cell tumors. These changes are accompanied by an increased sensitivity to interleukin 2 and antigen-specific unresponsiveness in T cell clones.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalEuropean Journal of Immunology
Volume15
Issue number2
Publication statusPublished - 1985

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Interleukin-2 Receptors
Phorbol Esters
Carcinogens
T-Lymphocytes
Antigens
Clone Cells
CD3 Antigens
Hybridomas
Tetradecanoylphorbol Acetate
Interleukin-2
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells. / Andó, I.; Hariri, G.; Wallace, D.; Beverley, P.

In: European Journal of Immunology, Vol. 15, No. 2, 1985, p. 196-199.

Research output: Contribution to journalArticle

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