Tumor cell growth kinetics

Research output: Contribution to journalArticle

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Abstract

The biological behaviour of a neoplasia is highly influenced by its growth rate determined by many intratumoral and microenvironmental factors. The intratumoral problems are related mainly to those genetic abnormalities which make the important pathways (e.g. pARF/mdm2/p53 or pINK4/cyclin D and dependent kinases/pRbs/E2F insensitive to normal regulation of proliferation and apoptosis leading to unbalanced accumulation of malignant cells. The local growth is complicated by invasion and distant metastases which are the result of a complex relationship between the tumor cells and the stroma (extracellular matrix and host cells). These interactions decide whether the given microenvironment could support the further tumor growth.

Original languageEnglish
Pages (from-to)141-143
Number of pages3
JournalCME Journal of Gynecologic Oncology
Volume6
Issue number2
Publication statusPublished - 2001

Fingerprint

Growth
Cyclin D
Neoplasms
Cyclin-Dependent Kinases
Extracellular Matrix
Apoptosis
Neoplasm Metastasis

Keywords

  • Cell cycle regulation
  • Stroma formation
  • Tumor growth kinetics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Tumor cell growth kinetics. / Kópper, L.

In: CME Journal of Gynecologic Oncology, Vol. 6, No. 2, 2001, p. 141-143.

Research output: Contribution to journalArticle

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