Tubulitis in primary vascular and glomerular renal disease

B. lványi, N. Marcussen, S. Olsen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A semiquantitative light microscopic study of 274 renal biopsy and 12 nephrectomy specimens was carried out to assess the frequency and severity o f tubulitis (mononuclear leukocytes in the renal tubular wall) in all common glomerular diseases, diabetic nephropathy, renal amyloidosis and renal artery stenosis. The extent o f interstitial inflammatory infiltrates and severity o f interstitial fibrosis were also graded. Tubulitis was 1) frequent in crescentic glomerulonephritis (GN) with pauci-immune, linear and granular immune deposits, renal artery stenosis, diabetic nephropathy, lupus GN o f WHO type IV, and IgA GN; 2) rare in minimal change and idiopathic membranous nephropathy; 3) usually severe in crescentic GN and renal artery stenosis; and 4) predominantly located in atrophic tubules in renal artery stenosis, diabetic nephropathy and IgA GN. The most important parameter for the grading o f tubulitis was interstitial infiltration. However, no correlation was found between the grades o f tubulitis, interstitial infiltrates and interstitial fibrosis in crescentic and lupus GN. It is suggested that renal ischemic injury, by eliciting expression o f groin flammatory cytokines and neo-antigens in the tubulointerstitial space, might play a role in the development o f tubulitis in vascular and glomerular renal diseases.

Original languageEnglish
Pages (from-to)1245-1251
Number of pages7
JournalPathology Research and Practice
Volume191
Issue number12
DOIs
Publication statusPublished - 1995

Keywords

  • Crescent
  • Diabetic nephropathy
  • Renal amyloidosis
  • Renal artery stenosis
  • Renal ischemia
  • Tubulitis, glomerulonephritis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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