Tubulitis in primary vascular and glomerular renal disease

B. Iványi, N. Marcussen, S. Olsen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A semiquantitative light microscopic study of 274 renal biopsy and 12 nephrectomy specimens was carried out to assess the frequency and severity of tubulitis (mononuclear leukocytes in the renal tubular wall) in all common glomerular diseases, diabetic nephropathy, renal amyloidosis and renal artery stenosis. The extent of interstitial inflammatory infiltrates and severity of interstitial fibrosis were also graded. Tubulitis was 1) frequent in crescentic glomerulonephritis (GN) with pauci-immune, linear and granular immune deposits, renal artery stenosis, diabetic nephropathy, lupus GN of WHO type IV, and IgA GN; 2) rare in minimal change and idiopathic membranous nephropathy; 3) usually severe in crescentic GN and renal artery stenosis; and 4) predominantly located in atrophic tubules in renal artery stenosis, diabetic nephropathy and IgA GN. The most important parameter for the grading of tubulitis was interstitial infiltration. However, no correlation was found between the grades of tubulitis, interstitial infiltrates and interstitial fibrosis in crescentic and lupus GN. It is suggested that renal ischemic injury, by eliciting expression of proinflammatory cytokines and neo-antigens in the tubulointerstitial space, might play a role in the development of tubulitis in vascular and glomerular renal diseases.

Original languageEnglish
Pages (from-to)1245-1251
Number of pages7
JournalPathology Research and Practice
Volume191
Issue number12
Publication statusPublished - 1995

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Renal Artery Obstruction
Blood Vessels
Glomerulonephritis
Kidney
Diabetic Nephropathies
Lupus Nephritis
Immunoglobulin A
Fibrosis
Mononuclear Leukocytes
Membranous Glomerulonephritis
Amyloidosis
Nephrectomy
Cytokines
Biopsy
Light
Antigens
Wounds and Injuries

Keywords

  • Crescent
  • Diabetic nephropathy
  • Renal amyloidosis
  • Renal artery stenosis
  • Renal ischemia
  • Tubulitis, glomerulonephritis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tubulitis in primary vascular and glomerular renal disease. / Iványi, B.; Marcussen, N.; Olsen, S.

In: Pathology Research and Practice, Vol. 191, No. 12, 1995, p. 1245-1251.

Research output: Contribution to journalArticle

Iványi, B, Marcussen, N & Olsen, S 1995, 'Tubulitis in primary vascular and glomerular renal disease', Pathology Research and Practice, vol. 191, no. 12, pp. 1245-1251.
Iványi, B. ; Marcussen, N. ; Olsen, S. / Tubulitis in primary vascular and glomerular renal disease. In: Pathology Research and Practice. 1995 ; Vol. 191, No. 12. pp. 1245-1251.
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