Tubocurarine and pancuronium inhibit evoked release of acetylcholine from the mouse hemidiaphragm preparation

E. S. Vizi, G. T. Somogyi, H. Nagashima, D. Duncalf, I. A. Chaudhry, O. Kobayashi, P. L. Goldiner, F. F. Foldes

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Abstract

Using a sensitive radioactive method that measures selectively the evoked release of acetylcholine, it was demonstrated that, when stimulating at 50 Hz, tubocurarine or pan-curonium 2×10* mo I litrel or hexamethonium 10-3 mol litre-1 significantly decreased the evoked release of acetylcholine in the mouse in vitro phrenic preparation.

Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalBritish Journal of Anaesthesia
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 1987

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    Vizi, E. S., Somogyi, G. T., Nagashima, H., Duncalf, D., Chaudhry, I. A., Kobayashi, O., Goldiner, P. L., & Foldes, F. F. (1987). Tubocurarine and pancuronium inhibit evoked release of acetylcholine from the mouse hemidiaphragm preparation. British Journal of Anaesthesia, 59(2), 226-231. https://doi.org/10.1093/bja/59.2.226