TTC post-processing is beneficial for functional MRI at low magnetic field: A comparative study at 1 T and 3 T

Attila Schwarcz, Tibor Auer, J. Janszky, T. Dóczi, Klaus Dietmar Merboldt, Jens Frahm

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study aimed to broaden the diagnostic possibilities of low-field MRI systems (i) by examining the feasibility of functional MRI of human brain activation at 1 T, and (ii) by assessing its reliability in comparison with acquisitions at 3 T. Eight subjects were studied at 1 T and 3T using standard echo-planar-imaging sequences at 3-mm isotropic spatial resolution. Paradigms included silent word generation, sequential finger-to-thumb opposition, and passive finger movements. Image post-processing was carried out either with statistical parametric mapping (SPM5, single-subject and group analysis) or with a two-threshold correlation (TTC, single-subject analysis only) analysis. Single-subject analysis with SPM5 resulted in 3-5 times more activated pixels at 3 T than at 1 T in the examined Broca and sensorimotor regions. By comparison, the TTC single-subject analysis yielded the same amount of activated pixels at 3 T and 1 T. Moreover, this number was identical to that obtained with SPM at 3 T. The group analysis with SPM5 resulted in very similar numbers of activated pixels at both field strengths. The present findings suggest that a field strength of 1 T combined with adequate post-processing allows for reliable functional MRI studies of human brain activation. High-field advantages are therefore best invested in higher spatial resolution.

Original languageEnglish
Pages (from-to)2594-2600
Number of pages7
JournalEuropean Radiology
Volume18
Issue number11
DOIs
Publication statusPublished - 2008

Fingerprint

Magnetic Fields
Fingers
Magnetic Resonance Imaging
Echo-Planar Imaging
Thumb
Brain
Broca Area

Keywords

  • Comparative study
  • Functional MRI
  • High field
  • Low field
  • Post-processing

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

TTC post-processing is beneficial for functional MRI at low magnetic field : A comparative study at 1 T and 3 T. / Schwarcz, Attila; Auer, Tibor; Janszky, J.; Dóczi, T.; Merboldt, Klaus Dietmar; Frahm, Jens.

In: European Radiology, Vol. 18, No. 11, 2008, p. 2594-2600.

Research output: Contribution to journalArticle

Schwarcz, Attila ; Auer, Tibor ; Janszky, J. ; Dóczi, T. ; Merboldt, Klaus Dietmar ; Frahm, Jens. / TTC post-processing is beneficial for functional MRI at low magnetic field : A comparative study at 1 T and 3 T. In: European Radiology. 2008 ; Vol. 18, No. 11. pp. 2594-2600.
@article{7b8d78130a944abcbaad00cf95993ec8,
title = "TTC post-processing is beneficial for functional MRI at low magnetic field: A comparative study at 1 T and 3 T",
abstract = "This study aimed to broaden the diagnostic possibilities of low-field MRI systems (i) by examining the feasibility of functional MRI of human brain activation at 1 T, and (ii) by assessing its reliability in comparison with acquisitions at 3 T. Eight subjects were studied at 1 T and 3T using standard echo-planar-imaging sequences at 3-mm isotropic spatial resolution. Paradigms included silent word generation, sequential finger-to-thumb opposition, and passive finger movements. Image post-processing was carried out either with statistical parametric mapping (SPM5, single-subject and group analysis) or with a two-threshold correlation (TTC, single-subject analysis only) analysis. Single-subject analysis with SPM5 resulted in 3-5 times more activated pixels at 3 T than at 1 T in the examined Broca and sensorimotor regions. By comparison, the TTC single-subject analysis yielded the same amount of activated pixels at 3 T and 1 T. Moreover, this number was identical to that obtained with SPM at 3 T. The group analysis with SPM5 resulted in very similar numbers of activated pixels at both field strengths. The present findings suggest that a field strength of 1 T combined with adequate post-processing allows for reliable functional MRI studies of human brain activation. High-field advantages are therefore best invested in higher spatial resolution.",
keywords = "Comparative study, Functional MRI, High field, Low field, Post-processing",
author = "Attila Schwarcz and Tibor Auer and J. Janszky and T. D{\'o}czi and Merboldt, {Klaus Dietmar} and Jens Frahm",
year = "2008",
doi = "10.1007/s00330-008-1046-2",
language = "English",
volume = "18",
pages = "2594--2600",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "11",

}

TY - JOUR

T1 - TTC post-processing is beneficial for functional MRI at low magnetic field

T2 - A comparative study at 1 T and 3 T

AU - Schwarcz, Attila

AU - Auer, Tibor

AU - Janszky, J.

AU - Dóczi, T.

AU - Merboldt, Klaus Dietmar

AU - Frahm, Jens

PY - 2008

Y1 - 2008

N2 - This study aimed to broaden the diagnostic possibilities of low-field MRI systems (i) by examining the feasibility of functional MRI of human brain activation at 1 T, and (ii) by assessing its reliability in comparison with acquisitions at 3 T. Eight subjects were studied at 1 T and 3T using standard echo-planar-imaging sequences at 3-mm isotropic spatial resolution. Paradigms included silent word generation, sequential finger-to-thumb opposition, and passive finger movements. Image post-processing was carried out either with statistical parametric mapping (SPM5, single-subject and group analysis) or with a two-threshold correlation (TTC, single-subject analysis only) analysis. Single-subject analysis with SPM5 resulted in 3-5 times more activated pixels at 3 T than at 1 T in the examined Broca and sensorimotor regions. By comparison, the TTC single-subject analysis yielded the same amount of activated pixels at 3 T and 1 T. Moreover, this number was identical to that obtained with SPM at 3 T. The group analysis with SPM5 resulted in very similar numbers of activated pixels at both field strengths. The present findings suggest that a field strength of 1 T combined with adequate post-processing allows for reliable functional MRI studies of human brain activation. High-field advantages are therefore best invested in higher spatial resolution.

AB - This study aimed to broaden the diagnostic possibilities of low-field MRI systems (i) by examining the feasibility of functional MRI of human brain activation at 1 T, and (ii) by assessing its reliability in comparison with acquisitions at 3 T. Eight subjects were studied at 1 T and 3T using standard echo-planar-imaging sequences at 3-mm isotropic spatial resolution. Paradigms included silent word generation, sequential finger-to-thumb opposition, and passive finger movements. Image post-processing was carried out either with statistical parametric mapping (SPM5, single-subject and group analysis) or with a two-threshold correlation (TTC, single-subject analysis only) analysis. Single-subject analysis with SPM5 resulted in 3-5 times more activated pixels at 3 T than at 1 T in the examined Broca and sensorimotor regions. By comparison, the TTC single-subject analysis yielded the same amount of activated pixels at 3 T and 1 T. Moreover, this number was identical to that obtained with SPM at 3 T. The group analysis with SPM5 resulted in very similar numbers of activated pixels at both field strengths. The present findings suggest that a field strength of 1 T combined with adequate post-processing allows for reliable functional MRI studies of human brain activation. High-field advantages are therefore best invested in higher spatial resolution.

KW - Comparative study

KW - Functional MRI

KW - High field

KW - Low field

KW - Post-processing

UR - http://www.scopus.com/inward/record.url?scp=54049155720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54049155720&partnerID=8YFLogxK

U2 - 10.1007/s00330-008-1046-2

DO - 10.1007/s00330-008-1046-2

M3 - Article

C2 - 18523777

AN - SCOPUS:54049155720

VL - 18

SP - 2594

EP - 2600

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 11

ER -