Tryptophan catabolites and migraine

Zsuzsanna Bohár, A. Párdutz, L. Vécsei

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Migraine is a highly disabling neurological condition affecting around 15% of the population worldwide. Decades of intensive research shed some light on diseases pathomechanism, but information is still missing about the initiation of the attack. In the past century, serotonin emerged as the main target of both basic and therapeutic research. As a result, the triptans, the only approved migraine specific drugs were developed. The involvement of glutamatergic mechanism in migraine headache development such as cortical hyperexcitability, and cortical spreading depression as the pathological correlate of migraine aura called the attention to the kynurenine pathway in migraine pathomechanism. The serotonin and kynurenine pathways are closely connected, as they both are the metabolic routes of the amino acid tryptophan. Kynurenine catabolites are important participants in glutamatergic neurotransmission, regulation also nociceptive processing of the trigeminal system. The current work attempts to collect recent data on both serotonin and kynurenine research related to migraine and emphasizes the importance of further research on this topic.

Original languageEnglish
Pages (from-to)1013-1021
Number of pages9
JournalCurrent Pharmaceutical Design
Volume22
Issue number8
Publication statusPublished - Mar 1 2016

Fingerprint

Migraine Disorders
Tryptophan
Kynurenine
Serotonin
Research
Cortical Spreading Depression
Tryptamines
Therapeutic Human Experimentation
Synaptic Transmission
Epilepsy
Amino Acids
Pharmaceutical Preparations
Population

Keywords

  • Cortical spreading depression
  • Glutamate
  • Hyperexcitability
  • Kynurenine pathway
  • Migraine
  • Serotonin

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Tryptophan catabolites and migraine. / Bohár, Zsuzsanna; Párdutz, A.; Vécsei, L.

In: Current Pharmaceutical Design, Vol. 22, No. 8, 01.03.2016, p. 1013-1021.

Research output: Contribution to journalArticle

Bohár, Zsuzsanna ; Párdutz, A. ; Vécsei, L. / Tryptophan catabolites and migraine. In: Current Pharmaceutical Design. 2016 ; Vol. 22, No. 8. pp. 1013-1021.
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