Trypsin-like activity of rat anterior pituitary in relation to secretory activity

Ágnes Kenessey, Piroska Páldi-Harris, Gábor B. Makara, László Graf

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Abstract

Biochemical changes in trypsin-like activity were studied in rat anterior pituitary during experimentally induced changes of hormone secretion. While dexamethasone and ACTH treatment of female rats led to a significant decrease of adenohypophyseal trypsin-like activity, elevated enzyme activity was observed after adrenalectomy and ovariectomy. This correlation together with our previous data on the subcellular localisation and some biochemical properties of the trypsin-like proteinases in the anterior pituitary suggests that these enzymes may be involved in the biosynthesis of some polypeptide hormones.

Original languageEnglish
Pages (from-to)437-443
Number of pages7
JournalLife Sciences
Volume25
Issue number5
DOIs
Publication statusPublished - Jul 30 1979

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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