Biochemical changes in trypsin-like activity were studied in rat anterior pituitary during experimentally induced changes of hormone secretion. While dexamethasone and ACTH treatment of female rats led to a significant decrease of adenohypophyseal trypsin-like activity, elevated enzyme activity was observed after adrenalectomy and ovariectomy. This correlation together with our previous data on the subcellular localisation and some biochemical properties of the trypsin-like proteinases in the anterior pituitary suggests that these enzymes may be involved in the biosynthesis of some polypeptide hormones.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)