Trypsin: Is there anything new under the Sun?

László Gráf, László Szilágyi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Though trypsin is the first discovered and probably the best characterized enzyme, recent studies have led to the discovery of new properties and even a new form of this enzyme. The molecular mechanisms of autolysis of both trypsin and chymotrypsin have recently been explored and it has been proposed that the elimination of the major autolytic site by mutation in human cationic trypsin might cause pancreatitis. Other highlights of trypsin research are the discovery, X-ray crystallography and immunohistochemical localization of human brain trypsin.

Original languageEnglish
Pages (from-to)481-485
Number of pages5
JournalJournal of Molecular Structure: THEOCHEM
Volume666-667
DOIs
Publication statusPublished - Dec 29 2003

Keywords

  • Autoactivation
  • Autolysis
  • Human brain trypsin
  • Pancreatitis
  • Trypsin

ASJC Scopus subject areas

  • Biochemistry
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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