TRPV3: Time to decipher a poorly understood family member!

Bernd Nilius, T. Bíró, Grzegorz Owsianik

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The vanilloid transient receptor potential channel TRPV3 differs in several aspects from other members of the TRPV subfamily. This Ca2+-, ATP- and calmodulin-regulated channel constitutes a target for many natural compounds and has a unique expression pattern as the most prominent and important TRP channel in keratinocytes of the skin. Although TRPV3 is considered as a thermosensitive channel, its function as a thermosensor in the skin is challenged. Nevertheless, it plays important roles in other skin functions such as cutaneous sensations, hair development and barrier function. More recently, mutations in TRPV3 were linked with a rare genodermatosis known as the Olmsted syndrome. This review gives an overview on properties of TRPV3 and its functions in the skin and skin diseases.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalJournal of Physiology
Volume592
Issue number2
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Skin
Transient Receptor Potential Channels
TRPV Cation Channels
Calmodulin
Keratinocytes
Skin Diseases
Hair
Adenosine Triphosphate
Mutation

ASJC Scopus subject areas

  • Physiology

Cite this

TRPV3 : Time to decipher a poorly understood family member! / Nilius, Bernd; Bíró, T.; Owsianik, Grzegorz.

In: Journal of Physiology, Vol. 592, No. 2, 01.2014, p. 295-304.

Research output: Contribution to journalArticle

Nilius, Bernd ; Bíró, T. ; Owsianik, Grzegorz. / TRPV3 : Time to decipher a poorly understood family member!. In: Journal of Physiology. 2014 ; Vol. 592, No. 2. pp. 295-304.
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