TRP channels in the skin

Balázs I. Tõth, Attila Oláh, Attila Gábor Szöllósi, T. Bíró

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several TRP channels in the development of certain skin diseases and identify future TRP channel-targeted therapeutic opportunities. Linked Articles This article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-10

Original languageEnglish
Pages (from-to)2568-2581
Number of pages14
JournalBritish Journal of Pharmacology
Volume171
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Transient Receptor Potential Channels
Skin
Sensory Receptor Cells
Ion Channels
Skin Diseases
Cell Differentiation
Cell Proliferation
Pharmacology

Keywords

  • Atopic dermatitis
  • Barrier
  • Differentiation
  • Inflammation
  • Skin
  • Transient receptor potential (TRP) channels

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Tõth, B. I., Oláh, A., Szöllósi, A. G., & Bíró, T. (2014). TRP channels in the skin. British Journal of Pharmacology, 171(10), 2568-2581. https://doi.org/10.1111/bph.12569

TRP channels in the skin. / Tõth, Balázs I.; Oláh, Attila; Szöllósi, Attila Gábor; Bíró, T.

In: British Journal of Pharmacology, Vol. 171, No. 10, 2014, p. 2568-2581.

Research output: Contribution to journalArticle

Tõth, BI, Oláh, A, Szöllósi, AG & Bíró, T 2014, 'TRP channels in the skin', British Journal of Pharmacology, vol. 171, no. 10, pp. 2568-2581. https://doi.org/10.1111/bph.12569
Tõth, Balázs I. ; Oláh, Attila ; Szöllósi, Attila Gábor ; Bíró, T. / TRP channels in the skin. In: British Journal of Pharmacology. 2014 ; Vol. 171, No. 10. pp. 2568-2581.
@article{7ca7943420e348adbf1c9b79f13adc25,
title = "TRP channels in the skin",
abstract = "Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several TRP channels in the development of certain skin diseases and identify future TRP channel-targeted therapeutic opportunities. Linked Articles This article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-10",
keywords = "Atopic dermatitis, Barrier, Differentiation, Inflammation, Skin, Transient receptor potential (TRP) channels",
author = "T{\~o}th, {Bal{\'a}zs I.} and Attila Ol{\'a}h and Sz{\"o}ll{\'o}si, {Attila G{\'a}bor} and T. B{\'i}r{\'o}",
year = "2014",
doi = "10.1111/bph.12569",
language = "English",
volume = "171",
pages = "2568--2581",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - TRP channels in the skin

AU - Tõth, Balázs I.

AU - Oláh, Attila

AU - Szöllósi, Attila Gábor

AU - Bíró, T.

PY - 2014

Y1 - 2014

N2 - Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several TRP channels in the development of certain skin diseases and identify future TRP channel-targeted therapeutic opportunities. Linked Articles This article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-10

AB - Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as 'polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several TRP channels in the development of certain skin diseases and identify future TRP channel-targeted therapeutic opportunities. Linked Articles This article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-10

KW - Atopic dermatitis

KW - Barrier

KW - Differentiation

KW - Inflammation

KW - Skin

KW - Transient receptor potential (TRP) channels

UR - http://www.scopus.com/inward/record.url?scp=84900789513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900789513&partnerID=8YFLogxK

U2 - 10.1111/bph.12569

DO - 10.1111/bph.12569

M3 - Article

VL - 171

SP - 2568

EP - 2581

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 10

ER -