Trophic effect of cholecystokinin-octapeptide in man - a new way in the treatment of chronic pancreatitis?

A. Pap, Zoltán Berger, Vince Varró

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effect of 3-week CCK-OP treatment on test meal stimulated pancreatic secretion was investigated in chronic pancreatitis patients. One drop of a 1 mg/ml CCK-OP solution applied intranasally, three times daily during 3 weeks resulted in a significant increase in volume, trypsin, lipase and amylase secretion in response to the Lundh test meal. Augmentation of trypsin secretion was the most pronounced. Functional capacity of pancreatic enzyme secretion remained elevated for 3 months after treatment. Nearly all patients became symptom free during and for some time after treatment. The results were attributed to a trophic effect of CCK-OP on human pancreas.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalDigestion
Volume21
Issue number3
DOIs
Publication statusPublished - 1981

Fingerprint

Sincalide
Chronic Pancreatitis
Trypsin
Meals
Amylases
Lipase
Pancreas
Therapeutics
Enzymes

Keywords

  • Cholecystokinin-octapeptide
  • Chronic pancreatitis
  • Response to test meal
  • Trophic effect

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Trophic effect of cholecystokinin-octapeptide in man - a new way in the treatment of chronic pancreatitis? / Pap, A.; Berger, Zoltán; Varró, Vince.

In: Digestion, Vol. 21, No. 3, 1981, p. 163-168.

Research output: Contribution to journalArticle

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