Tritium Labelling of Naltrindole, a δ‐Receptor‐Selective Opioid Antagonist via 1‐Bromonaltrexone

Géza Tóth, Ferenc Ötvös, Sándor Hosztafi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The synthesis of [1,5′‐3H2]naltrindole (9) with labels at both the morphine skeleton and the indole moiety was carried out by catalytic tritiodehalogenation of 1,5′‐dibromonaltrindole (8) resulting in a specific activity of 46.1 Ci/mmol (1705 GBq/mmol). The brominated precursor was prepared by the Fischer indole synthesis starting from 1‐bromonaltrexone (7) and (4‐bromophenyl)hydrazine.

Original languageEnglish
Pages (from-to)2274-2278
Number of pages5
JournalHelvetica Chimica Acta
Volume76
Issue number6
DOIs
Publication statusPublished - Sep 22 1993

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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