Tritium Labelling of Cyprodime ( = (—)‐17‐(Cyclopropylmethyl)‐4,14‐dimethoxymorphinan‐6‐one), a μ Receptor‐Selective Opioid Antagonist

Ferenc Ötvös, Géza Tóth, Helmut Schmidhammer

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The preparation of [1‐3H]cyprodime (2), which has a specific activity of 31.6 Ci/mmol was carried out by catalytic tritiodehalogenation of 1‐bromocyprodime (3). Bromination of cyprodime was performed by using chloroperoxidase, KBr, and H2O2.

Original languageEnglish
Pages (from-to)1718-1720
Number of pages3
JournalHelvetica Chimica Acta
Issue number5
Publication statusPublished - Aug 13 1992


ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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