Tritium labeling of 7-isopropoxyisoflavone

F. Ötvös, Géza Tóth, István Szatmári, Ferenc Lévai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Catalytic tritiodehalogenation of 8-bromoipriflavone and 6,8-dibromoipriflavone resulted in [8-3H]ipriflavone and [6,8-3H2]ipriflavone with specific activities of 1.08 TBq/mmol (29.2 Ci/mmol) and 1.94 TBq/mmol (52.4 Ci/mmol), respectively. 8-Bromoipriflavone was synthesized by direct bromination of ipriflavone, while 6,8-dibromoipriflavone was formed by isopropylation of the phenolic OH group of 6,8-dibromo-7-hydroxyisoflavone which itself was prepared from 7-hydroxyisoflavone and elemental bromine.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume42
Issue number5
DOIs
Publication statusPublished - 1999

Fingerprint

Tritium
Labeling
Bromine
Halogenation
ipriflavone
7-hydroxyisoflavone

Keywords

  • Bromination
  • Ipriflavone
  • Isoflavone
  • Osteopenia
  • Tritiation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Tritium labeling of 7-isopropoxyisoflavone. / Ötvös, F.; Tóth, Géza; Szatmári, István; Lévai, Ferenc.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 42, No. 5, 1999, p. 497-503.

Research output: Contribution to journalArticle

Ötvös, F. ; Tóth, Géza ; Szatmári, István ; Lévai, Ferenc. / Tritium labeling of 7-isopropoxyisoflavone. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1999 ; Vol. 42, No. 5. pp. 497-503.
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