Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke

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17 Citations (Scopus)

Abstract

Background: Recent genome-wide studies identified several genetic variants associated with blood lipid level alterations. Because affected lipid metabolism can confer risk to the development of ischaemic stroke, we studied three polymorphisms reportedly associated with triglyceride-level changes, rs17145738 and rs3812316 of the MLXIPL locus, and rs4846914 variant of GALNT2 gene in biobanked samples of patients with stroke. This pool of samples was previously investigated for haplotype tagging minor alleles of apolipoprotein A5 gene (T-1131C, T1259C, IVS3+G476A and C56G), and an association was found between the minor allele carriage and the triglyceride levels, and also these variants were found to confer risk to the development of stroke. Methods: Here, a total of 467 patients with stroke, stratified as large vessel, small vessel and mixed stroke groups, and 156 control subjects were genotyped using PCR-RFLP methods. Results: In the current study, we could not verify association of the variants analyzed either with triglyceride and total cholesterol levels or with the risk of ischaemic stroke susceptibility. Conclusions: The data presented here revealed differentiated risk nature of the triglyceride level modifying natural gene variants.

Original languageEnglish
Pages (from-to)1033-1039
Number of pages7
JournalEuropean Journal of Neurology
Volume17
Issue number8
DOIs
Publication statusPublished - 2010

Fingerprint

Triglycerides
Stroke
Alleles
Genes
Lipid Metabolism
Restriction Fragment Length Polymorphisms
Haplotypes
Cholesterol
Genome
Lipids
Polymerase Chain Reaction
Control Groups

Keywords

  • GALNT2
  • ischaemic stroke
  • MLXIPL
  • triglyceride

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

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title = "Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke",
abstract = "Background: Recent genome-wide studies identified several genetic variants associated with blood lipid level alterations. Because affected lipid metabolism can confer risk to the development of ischaemic stroke, we studied three polymorphisms reportedly associated with triglyceride-level changes, rs17145738 and rs3812316 of the MLXIPL locus, and rs4846914 variant of GALNT2 gene in biobanked samples of patients with stroke. This pool of samples was previously investigated for haplotype tagging minor alleles of apolipoprotein A5 gene (T-1131C, T1259C, IVS3+G476A and C56G), and an association was found between the minor allele carriage and the triglyceride levels, and also these variants were found to confer risk to the development of stroke. Methods: Here, a total of 467 patients with stroke, stratified as large vessel, small vessel and mixed stroke groups, and 156 control subjects were genotyped using PCR-RFLP methods. Results: In the current study, we could not verify association of the variants analyzed either with triglyceride and total cholesterol levels or with the risk of ischaemic stroke susceptibility. Conclusions: The data presented here revealed differentiated risk nature of the triglyceride level modifying natural gene variants.",
keywords = "GALNT2, ischaemic stroke, MLXIPL, triglyceride",
author = "N. Polg{\'a}r and L. J{\'a}romi and V. Cs{\"o}ngei and A. Ma{\'a}sz and C. Sipeky and E. S{\'a}fr{\'a}ny and M. Szab{\'o} and B. Melegh",
year = "2010",
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T1 - Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke

AU - Polgár, N.

AU - Járomi, L.

AU - Csöngei, V.

AU - Maász, A.

AU - Sipeky, C.

AU - Sáfrány, E.

AU - Szabó, M.

AU - Melegh, B.

PY - 2010

Y1 - 2010

N2 - Background: Recent genome-wide studies identified several genetic variants associated with blood lipid level alterations. Because affected lipid metabolism can confer risk to the development of ischaemic stroke, we studied three polymorphisms reportedly associated with triglyceride-level changes, rs17145738 and rs3812316 of the MLXIPL locus, and rs4846914 variant of GALNT2 gene in biobanked samples of patients with stroke. This pool of samples was previously investigated for haplotype tagging minor alleles of apolipoprotein A5 gene (T-1131C, T1259C, IVS3+G476A and C56G), and an association was found between the minor allele carriage and the triglyceride levels, and also these variants were found to confer risk to the development of stroke. Methods: Here, a total of 467 patients with stroke, stratified as large vessel, small vessel and mixed stroke groups, and 156 control subjects were genotyped using PCR-RFLP methods. Results: In the current study, we could not verify association of the variants analyzed either with triglyceride and total cholesterol levels or with the risk of ischaemic stroke susceptibility. Conclusions: The data presented here revealed differentiated risk nature of the triglyceride level modifying natural gene variants.

AB - Background: Recent genome-wide studies identified several genetic variants associated with blood lipid level alterations. Because affected lipid metabolism can confer risk to the development of ischaemic stroke, we studied three polymorphisms reportedly associated with triglyceride-level changes, rs17145738 and rs3812316 of the MLXIPL locus, and rs4846914 variant of GALNT2 gene in biobanked samples of patients with stroke. This pool of samples was previously investigated for haplotype tagging minor alleles of apolipoprotein A5 gene (T-1131C, T1259C, IVS3+G476A and C56G), and an association was found between the minor allele carriage and the triglyceride levels, and also these variants were found to confer risk to the development of stroke. Methods: Here, a total of 467 patients with stroke, stratified as large vessel, small vessel and mixed stroke groups, and 156 control subjects were genotyped using PCR-RFLP methods. Results: In the current study, we could not verify association of the variants analyzed either with triglyceride and total cholesterol levels or with the risk of ischaemic stroke susceptibility. Conclusions: The data presented here revealed differentiated risk nature of the triglyceride level modifying natural gene variants.

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