Triggering of respiratory burst by phagocytosis in monocytes of patients with systemic lupus erythematosus

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Abstract

The triggering of the respiratory burst by phagocytosis via different receptors in monocytes of patients with systemic lupus erythematosus (SLE) was investigated. The superoxide anion synthesis was assayed by reduction of ferricytochrome C that was inhibited by superoxide dismutase. The mononuclear cell suspensions were triggered by IgG-coated latex, C3 complement fragment-coated and uncoated yeast (Saccharomyces cerevisiae). Superoxide generation induced by phagocytosis via FcγR was decreased in monocytes of patients with SLE. On the other hand, MoAbs against FcγRI, FcγRII and especially CR3 could also induce superoxide anion synthesis. At the same time, superoxide generation induced by anti-CR3 could be inhibited with C3-coated yeast.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalClinical and Experimental Immunology
Volume94
Issue number1
DOIs
Publication statusPublished - 1993

Keywords

  • Fc gamma receptors
  • complement receptor 3
  • monocytes
  • superoxide anion
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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