Trigeminal ganglion innervates the auditory brainstem

Susan E. Shore, Z. Vass, Noel L. Wys, Richard A. Altschuler

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

A neural connection between the trigeminal ganglion and the auditory brainstem was investigated by using retrograde and anterograde tract tracing methods: iontophoretic injections of biocytin or biotinylated dextran-amine (BDA) were made into the guinea pig trigeminal ganglion, and anterograde labeling was examined in the cochlear nucleus and superior olivary complex. Terminal labeling after biocytin and BDA injections into the ganglion was found to be most dense in the marginal cell area and secondarily in the magnocellular area of the ventral cochlear nucleus (VCN). Anterograde and retrograde labeling was also seen in the shell regions of the lateral superior olivary complex and in periolivary regions. The labeling was seen in the neuropil, on neuronal somata, and in regions surrounding blood vessels. Retrograde labeling was investigated using either wheat-germ agglutinin- horseradish peroxidase (WGA-HRP), BDA, or a fluorescent tracer, iontophoretically injected into the VCN. Cells filled by retrograde labeling were found in the ophthalmic and mandibular divisions of the trigeminal ganglion. We have previously shown that these divisions project to the cochlea and middle ear, respectively. This study provides the first evidence that the trigeminal ganglion innervates the cochlear nucleus and superior olivary complex. This projection from a predominantly somatosensory ganglion may be related to integration mechanisms involving the auditory end organ and its central targets.

Original languageEnglish
Pages (from-to)271-285
Number of pages15
JournalJournal of Comparative Neurology
Volume419
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Cochlear Nucleus
Trigeminal Ganglion
Brain Stem
Ganglia
Wheat Germ Agglutinins
Injections
Neuropil
Cochlea
Carisoprodol
Middle Ear
Horseradish Peroxidase
Blood Vessels
Guinea Pigs
Superior Olivary Complex
biotinylated dextran amine
biocytin

Keywords

  • Cochlear nucleus
  • Lateral superior olivary complex
  • Olivocochlear
  • Pathways
  • Somatosensory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Trigeminal ganglion innervates the auditory brainstem. / Shore, Susan E.; Vass, Z.; Wys, Noel L.; Altschuler, Richard A.

In: Journal of Comparative Neurology, Vol. 419, No. 3, 2000, p. 271-285.

Research output: Contribution to journalArticle

Shore, Susan E. ; Vass, Z. ; Wys, Noel L. ; Altschuler, Richard A. / Trigeminal ganglion innervates the auditory brainstem. In: Journal of Comparative Neurology. 2000 ; Vol. 419, No. 3. pp. 271-285.
@article{dc4772c901b04cf5a562c4b88574ab76,
title = "Trigeminal ganglion innervates the auditory brainstem",
abstract = "A neural connection between the trigeminal ganglion and the auditory brainstem was investigated by using retrograde and anterograde tract tracing methods: iontophoretic injections of biocytin or biotinylated dextran-amine (BDA) were made into the guinea pig trigeminal ganglion, and anterograde labeling was examined in the cochlear nucleus and superior olivary complex. Terminal labeling after biocytin and BDA injections into the ganglion was found to be most dense in the marginal cell area and secondarily in the magnocellular area of the ventral cochlear nucleus (VCN). Anterograde and retrograde labeling was also seen in the shell regions of the lateral superior olivary complex and in periolivary regions. The labeling was seen in the neuropil, on neuronal somata, and in regions surrounding blood vessels. Retrograde labeling was investigated using either wheat-germ agglutinin- horseradish peroxidase (WGA-HRP), BDA, or a fluorescent tracer, iontophoretically injected into the VCN. Cells filled by retrograde labeling were found in the ophthalmic and mandibular divisions of the trigeminal ganglion. We have previously shown that these divisions project to the cochlea and middle ear, respectively. This study provides the first evidence that the trigeminal ganglion innervates the cochlear nucleus and superior olivary complex. This projection from a predominantly somatosensory ganglion may be related to integration mechanisms involving the auditory end organ and its central targets.",
keywords = "Cochlear nucleus, Lateral superior olivary complex, Olivocochlear, Pathways, Somatosensory",
author = "Shore, {Susan E.} and Z. Vass and Wys, {Noel L.} and Altschuler, {Richard A.}",
year = "2000",
doi = "10.1002/(SICI)1096-9861(20000410)419:3<271::AID-CNE1>3.0.CO;2-M",
language = "English",
volume = "419",
pages = "271--285",
journal = "Journal of Comparative Neurology",
issn = "0021-9967",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Trigeminal ganglion innervates the auditory brainstem

AU - Shore, Susan E.

AU - Vass, Z.

AU - Wys, Noel L.

AU - Altschuler, Richard A.

PY - 2000

Y1 - 2000

N2 - A neural connection between the trigeminal ganglion and the auditory brainstem was investigated by using retrograde and anterograde tract tracing methods: iontophoretic injections of biocytin or biotinylated dextran-amine (BDA) were made into the guinea pig trigeminal ganglion, and anterograde labeling was examined in the cochlear nucleus and superior olivary complex. Terminal labeling after biocytin and BDA injections into the ganglion was found to be most dense in the marginal cell area and secondarily in the magnocellular area of the ventral cochlear nucleus (VCN). Anterograde and retrograde labeling was also seen in the shell regions of the lateral superior olivary complex and in periolivary regions. The labeling was seen in the neuropil, on neuronal somata, and in regions surrounding blood vessels. Retrograde labeling was investigated using either wheat-germ agglutinin- horseradish peroxidase (WGA-HRP), BDA, or a fluorescent tracer, iontophoretically injected into the VCN. Cells filled by retrograde labeling were found in the ophthalmic and mandibular divisions of the trigeminal ganglion. We have previously shown that these divisions project to the cochlea and middle ear, respectively. This study provides the first evidence that the trigeminal ganglion innervates the cochlear nucleus and superior olivary complex. This projection from a predominantly somatosensory ganglion may be related to integration mechanisms involving the auditory end organ and its central targets.

AB - A neural connection between the trigeminal ganglion and the auditory brainstem was investigated by using retrograde and anterograde tract tracing methods: iontophoretic injections of biocytin or biotinylated dextran-amine (BDA) were made into the guinea pig trigeminal ganglion, and anterograde labeling was examined in the cochlear nucleus and superior olivary complex. Terminal labeling after biocytin and BDA injections into the ganglion was found to be most dense in the marginal cell area and secondarily in the magnocellular area of the ventral cochlear nucleus (VCN). Anterograde and retrograde labeling was also seen in the shell regions of the lateral superior olivary complex and in periolivary regions. The labeling was seen in the neuropil, on neuronal somata, and in regions surrounding blood vessels. Retrograde labeling was investigated using either wheat-germ agglutinin- horseradish peroxidase (WGA-HRP), BDA, or a fluorescent tracer, iontophoretically injected into the VCN. Cells filled by retrograde labeling were found in the ophthalmic and mandibular divisions of the trigeminal ganglion. We have previously shown that these divisions project to the cochlea and middle ear, respectively. This study provides the first evidence that the trigeminal ganglion innervates the cochlear nucleus and superior olivary complex. This projection from a predominantly somatosensory ganglion may be related to integration mechanisms involving the auditory end organ and its central targets.

KW - Cochlear nucleus

KW - Lateral superior olivary complex

KW - Olivocochlear

KW - Pathways

KW - Somatosensory

UR - http://www.scopus.com/inward/record.url?scp=0034088855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034088855&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-9861(20000410)419:3<271::AID-CNE1>3.0.CO;2-M

DO - 10.1002/(SICI)1096-9861(20000410)419:3<271::AID-CNE1>3.0.CO;2-M

M3 - Article

VL - 419

SP - 271

EP - 285

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

IS - 3

ER -