Tricellulin expression and its prognostic significance in primary liver carcinomas

Áron Somorácz, Anna Korompay, Péter Törzsök, Attila Patonai, Boglárka Erdélyi-Belle, G. Lotz, Z. Schaff, András Kiss

Research output: Contribution to journalArticle

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Abstract

Numerous data suggest that altered expression of tight junction proteins such as occludin and claudins plays important role in carcinogenesis. However, little is known about tricellulin, a transmembrane tight junction protein concentrated where three epithelial cells meet. We aimed to characterize tricellulin expression in normal and cirrhotic liver in comparison to primary hepatic neoplasms. Tricellulin expression of 20 control livers, 12 cirrhotic livers, 32 hepatocellular carcinomas (HCC), and 20 intrahepatic cholangiocarcinomas (iCCC) was investigated by immunohistochemistry and Western blotting. Co-localization of tricellulin with claudin-1, -4, and MRP2 was studied using double immunofluorescence. Scattered tricellulin immunopositivity was restricted to biliary pole of hepatocytes confirmed by co-localization with MRP2. Moreover, spotted-like reaction was observed between bile duct epithelial cells. In 40 % of HCCs marked tricellulin overexpression was measured regardless of tumor grades. In iCCCs, however, tricellulin expression decreased parallel with dedifferentiation. In HCCs high tricellulin expression, in iCCCs low tricellulin expression correlated with poor prognosis. Co-localization with MRP2 might substantiate that tricellulin plays role in blood-biliary barrier. Overexpressed tricellulin in a subset of HCCs correlated with unfavorable prognosis. Similar to ductal pancreatic adenocarcinoma, higher grades of iCCCs were associated with decreased tricellulin expression correlating with poor prognosis.

Original languageEnglish
Pages (from-to)755-764
Number of pages10
JournalPathology and Oncology Research
Volume20
Issue number4
DOIs
Publication statusPublished - Oct 1 2014

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MARVEL Domain Containing 2 Protein
Carcinoma
Liver
Tight Junction Proteins
Claudin-4
Epithelial Cells
Claudins
Claudin-1
Occludin
Cholangiocarcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Somorácz, Á., Korompay, A., Törzsök, P., Patonai, A., Erdélyi-Belle, B., Lotz, G., ... Kiss, A. (2014). Tricellulin expression and its prognostic significance in primary liver carcinomas. Pathology and Oncology Research, 20(4), 755-764. https://doi.org/10.1007/s12253-014-9758-x

Tricellulin expression and its prognostic significance in primary liver carcinomas. / Somorácz, Áron; Korompay, Anna; Törzsök, Péter; Patonai, Attila; Erdélyi-Belle, Boglárka; Lotz, G.; Schaff, Z.; Kiss, András.

In: Pathology and Oncology Research, Vol. 20, No. 4, 01.10.2014, p. 755-764.

Research output: Contribution to journalArticle

Somorácz, Á, Korompay, A, Törzsök, P, Patonai, A, Erdélyi-Belle, B, Lotz, G, Schaff, Z & Kiss, A 2014, 'Tricellulin expression and its prognostic significance in primary liver carcinomas', Pathology and Oncology Research, vol. 20, no. 4, pp. 755-764. https://doi.org/10.1007/s12253-014-9758-x
Somorácz, Áron ; Korompay, Anna ; Törzsök, Péter ; Patonai, Attila ; Erdélyi-Belle, Boglárka ; Lotz, G. ; Schaff, Z. ; Kiss, András. / Tricellulin expression and its prognostic significance in primary liver carcinomas. In: Pathology and Oncology Research. 2014 ; Vol. 20, No. 4. pp. 755-764.
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