Tribbles: Novel regulators of cell function; evolutionary aspects

Z. Hegedus, A. Czibula, E. Kiss-Toth

Research output: Contribution to journalReview article

68 Citations (Scopus)


Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several 'independent' signal processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the various interacting signalling pathways and therefore appear to be key in determining cell fate while responding to environmental challenges. This review summarises our current understanding of tribbles function and also provides an evolutionary perspective on the various tribbles genes.

Original languageEnglish
Pages (from-to)1632-1641
Number of pages10
JournalCellular and Molecular Life Sciences
Issue number14
Publication statusPublished - Jul 2006


  • ATF4
  • Akt
  • MAPK
  • Regulation of signalling
  • Scaffolds
  • Signal transduction
  • Tribbles

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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