Trends in the birth prevalence of boys with isolated hypospadias and undescended testis in hungary during the last 50 years: A population-based study

Stelios Mavrogenis, E. Czeizel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Previously an increasing birth prevalence of hypospadias and undescended testis was recorded in some countries, including in the Hungarian Congenital Abnormality Registry, 1962-2011, i.e., during the last 50 years. However, the critical evaluation of cases with recorded isolated hypospadias (IHS) and isolated undescended testis (IUT), particularly to compare with the so-called reference birth prevalence of IHS (2.25 + 0.30 per 1000 live-births) and IUT (6.86 + 0.62 per 1000 live-births) determined in a Hungarian clinical-epidemiological study based on the physical examination of newborns with welldefined diagnostic criteria did not indicate a real increase in the birth prevalence of IHS and IUT. Thus, the increase of recorded cases with IHS and IUT can be explained by the more complete reporting of cases and a larger proportion of mild subgroup of IHS and the lack of differentiation between birth IUT (with many postnatal descents of testes) and true IUT (diagnosed at 3,5 months after birth). In conclusion, birth defect-registries are not appropriate for the estimation of real birth prevalence of IHS and IUT. In addition the socio-demographic variables of mothers were also analyzed without significant association of changes in birth prevalence of recorded IHS and IUT. Finally maternal risk factors were evaluated in the large population-based Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996, some of them showed association with the risk of IHS and IUT but without connection of the trend in the birth prevalence of cases with IHS and IUT.

Original languageEnglish
Title of host publicationAdvances in Medicine and Biology
PublisherNova Science Publishers, Inc.
Pages1-43
Number of pages43
Volume87
ISBN (Print)9781634830089, 9781634829724
Publication statusPublished - Jul 1 2015

Keywords

  • Birth defect registries
  • Birth outcomes
  • Hypospadias
  • Increased birth prevalence
  • Population based study
  • Risk factors
  • Socio-demographic variables of mothers
  • Undescended testis

ASJC Scopus subject areas

  • Medicine(all)

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    Mavrogenis, S., & Czeizel, E. (2015). Trends in the birth prevalence of boys with isolated hypospadias and undescended testis in hungary during the last 50 years: A population-based study. In Advances in Medicine and Biology (Vol. 87, pp. 1-43). Nova Science Publishers, Inc..