Treatment with ranitidine of ischemic brain edema

A. Tósaki, Péter Szerdahelyi, Ferenc Joó

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Cerebral ischemia was produced by bilateral common carotid artery occlusion in female Sprague-Dawley rats. Ranitidine, a histamine H2 receptor blocking agent, given intraperitoneally 30 min prior to ischemia, exerted a dose-dependent protective effect on water accumulation and ion shifts in the brain (Na+, K+ and Ca2+). To decide whether ranitidine can prevent ischemia-induced brain edema when given in the postischemic period, ranitidine (10 mg/kg i.p.) was administered 1, 2, and 3 h respectively after the onset of cerebral ischemia. Early (1 h) postocclusion treatment was still able to attenuate the ischemia-induced water accumulation and maldistribution of ions in the brain tissue.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalEuropean Journal of Pharmacology
Volume264
Issue number3
DOIs
Publication statusPublished - Nov 3 1994

Fingerprint

Ranitidine
Brain Edema
Ischemia
Brain Ischemia
Ions
Histamine H2 Receptors
Water
Common Carotid Artery
Brain
Sprague Dawley Rats

Keywords

  • (Rat)
  • Brain ischemia
  • Ca
  • Edema
  • Histamine H receptor
  • K
  • Na
  • Ranitidine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Treatment with ranitidine of ischemic brain edema. / Tósaki, A.; Szerdahelyi, Péter; Joó, Ferenc.

In: European Journal of Pharmacology, Vol. 264, No. 3, 03.11.1994, p. 455-458.

Research output: Contribution to journalArticle

Tósaki, A. ; Szerdahelyi, Péter ; Joó, Ferenc. / Treatment with ranitidine of ischemic brain edema. In: European Journal of Pharmacology. 1994 ; Vol. 264, No. 3. pp. 455-458.
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