Treatment with ranitidine of ischemic brain edema

Árpád Tósaki, Péter Szerdahelyi, Ferenc Joó

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Cerebral ischemia was produced by bilateral common carotid artery occlusion in female Sprague-Dawley rats. Ranitidine, a histamine H2 receptor blocking agent, given intraperitoneally 30 min prior to ischemia, exerted a dose-dependent protective effect on water accumulation and ion shifts in the brain (Na+, K+ and Ca2+). To decide whether ranitidine can prevent ischemia-induced brain edema when given in the postischemic period, ranitidine (10 mg/kg i.p.) was administered 1, 2, and 3 h respectively after the onset of cerebral ischemia. Early (1 h) postocclusion treatment was still able to attenuate the ischemia-induced water accumulation and maldistribution of ions in the brain tissue.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number3
Publication statusPublished - Nov 3 1994



  • (Rat)
  • Brain ischemia
  • Ca
  • Edema
  • Histamine H receptor
  • K
  • Na
  • Ranitidine

ASJC Scopus subject areas

  • Pharmacology

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