A várandósság alatti emlorák kezelése

Translated title of the contribution: Treatment of pregnancy associated breast cancer

Borbála Székely, Zoltán Langmár, Krisztián Somlai, Gyöngyvér Szentmártoni, Klára Szalay, Anna Korompay, A. Szász, J. Kulka, F. Bánhidy, Magdolna Dank

Research output: Contribution to journalArticle

Abstract

Pregnancy-associated breast cancer (PABC) is defined as cancer of the breast diagnosed during pregnancy and up to 1 year postpartum. The crude incidence is 1/3000 pregnant women. As women delay childbearing the incidence of PABC increases with age. Young patients with PABC do not have worse prognosis compared with those with non-PABC; however, pregnancy can contribute to a delay in breast cancer diagnosis, evaluation, and treatment. Primary care physicians and gynecologists should be careful in the thorough workup of breast symptoms in the pregnant population to expedite diagnosis and allow multidisciplinary treatment as early as possible following the established diagnosis. Authors report a case of a 30-year-old pregnant woman, who detected inflammatory signs of her right breast and a palpable axillary mass at the 21st week of gestation. Her symptoms did not improve with administration of antibiotics. Therefore fine needle aspiration biopsy of the axillary lump was performed, with the result of unequivocal diagnosis of metastatic invasive carcinoma. The patient was referred to the multidisciplinary tumor board of our Department at the 27st week of gestation with the symptoms of inflammatory breast cancer, palpable right axillary and supraclavicular lymph nodes. Core biopsy showed an ER and PR negative, Her-2 positive, grade 3, infiltrating ductal carcinoma of the breast. After multidisciplinary team consultation the patient declined any kind of therapy during her pregnancy. On the 30th week of gestation caesarean section was performed. The premature baby girl was treated in the Neonatal Intensive Care Unit. Imaging modalities revealed no evidence of distant metastases short after the delivery. After 6 cycles of chemotherapy (docetaxel-doxorubicin- cycclophosphamid) the patient underwent right mastectomy and axillary lymph node dissection. Complete pathological response was diagnosed, since no residual tumor was found in the surgical resection specimen. After radiotherapy, trastuzumab medication was initiated. To date, there is no evidence of local recurrence or distant metastases during her 24 months follow-up. The newborn is on close neurohabilitation folow-up due to the evidence of generalized muscle dystonia. Had the patient accepted chemotherapy, the damage of the newborn baby would have been avoidable.

Original languageHungarian
Pages (from-to)1299-1303
Number of pages5
JournalOrvosi Hetilap
Volume151
Issue number32
DOIs
Publication statusPublished - Aug 1 2010

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Second Primary Neoplasms
Breast Neoplasms
Pregnancy
docetaxel
Pregnant Women
Breast
Inflammatory Breast Neoplasms
Newborn Infant
Neoplasm Metastasis
Carcinoma, Ductal, Breast
Drug Therapy
Dystonia
Neonatal Intensive Care Units
Mastectomy
Incidence
Residual Neoplasm
Primary Care Physicians
Patient Rights
Fine Needle Biopsy
Lymph Node Excision

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Székely, B., Langmár, Z., Somlai, K., Szentmártoni, G., Szalay, K., Korompay, A., ... Dank, M. (2010). A várandósság alatti emlorák kezelése. Orvosi Hetilap, 151(32), 1299-1303. https://doi.org/10.1556/OH.2010.28886

A várandósság alatti emlorák kezelése. / Székely, Borbála; Langmár, Zoltán; Somlai, Krisztián; Szentmártoni, Gyöngyvér; Szalay, Klára; Korompay, Anna; Szász, A.; Kulka, J.; Bánhidy, F.; Dank, Magdolna.

In: Orvosi Hetilap, Vol. 151, No. 32, 01.08.2010, p. 1299-1303.

Research output: Contribution to journalArticle

Székely, B, Langmár, Z, Somlai, K, Szentmártoni, G, Szalay, K, Korompay, A, Szász, A, Kulka, J, Bánhidy, F & Dank, M 2010, 'A várandósság alatti emlorák kezelése', Orvosi Hetilap, vol. 151, no. 32, pp. 1299-1303. https://doi.org/10.1556/OH.2010.28886
Székely B, Langmár Z, Somlai K, Szentmártoni G, Szalay K, Korompay A et al. A várandósság alatti emlorák kezelése. Orvosi Hetilap. 2010 Aug 1;151(32):1299-1303. https://doi.org/10.1556/OH.2010.28886
Székely, Borbála ; Langmár, Zoltán ; Somlai, Krisztián ; Szentmártoni, Gyöngyvér ; Szalay, Klára ; Korompay, Anna ; Szász, A. ; Kulka, J. ; Bánhidy, F. ; Dank, Magdolna. / A várandósság alatti emlorák kezelése. In: Orvosi Hetilap. 2010 ; Vol. 151, No. 32. pp. 1299-1303.
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