Treatment of particles with low-flow properties

János Bajdik, K. Pintye-Hódi, Géza Regdon, I. Erös

Research output: Contribution to journalArticle

Abstract

The main problems which occur during the preparation of solid dosage forms (especially tablets and capsules) are the insufficient flow of the particles, poor compactibility and inadequate stability of the materials. The aim of preformulation, therefore, is to eliminate such problems, if possible. The effects of granulation and coating were examined. Dimenhydrinate was chosen as a model drug with low-flow properties and decomposition at the melting point. The shape of the particles and the flow properties (angle of repose, mass by volume, flow time, the Hausner factor and Carr's index) were determined. Differential scanning calorimetry was used to check the features of the sample on exposure to heat and to measure the melting point. The effect of the coating film on the melting point was observed during melting.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalDrugs Made in Germany
Volume45
Issue number1
Publication statusPublished - 2002

Fingerprint

Freezing
Dimenhydrinate
Differential Scanning Calorimetry
Dosage Forms
Tablets
Capsules
Hot Temperature
Pharmaceutical Preparations

Keywords

  • Differential scanning calorimetry
  • Dimenhydrinate
  • Film coating
  • Hydroxypropylcellulose
  • Particles, agglomeration, flow properties
  • Solid dosage forms

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology

Cite this

Treatment of particles with low-flow properties. / Bajdik, János; Pintye-Hódi, K.; Regdon, Géza; Erös, I.

In: Drugs Made in Germany, Vol. 45, No. 1, 2002, p. 25-29.

Research output: Contribution to journalArticle

Bajdik, János ; Pintye-Hódi, K. ; Regdon, Géza ; Erös, I. / Treatment of particles with low-flow properties. In: Drugs Made in Germany. 2002 ; Vol. 45, No. 1. pp. 25-29.
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