Treatment of drug-induced bone marrow suppression with recombinant human granulocyte/monocyte colony stimulating factor

A. Somogyi, Andras Rosta, I. Láng, Klara Werling

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The haemopoietic growth factors are relatively new additions to the treatment of drug-induced bone marrow suppression. Treatment with growth factors may induce primitive cells to enter into cell cycle. In clinical practice they have beneficial effects on the neutropenia following cytotoxic chemotherapy, bone marrow transplantation, and it may be effective in severe chronic neutropenia by cause drugs. One of the classes of drugs which cause serious agranulcytosis are the antithyroid drugs. A thyrotoxic patient with methimazole-induced agranulocytosis was treated with recombinant human granulocyte-monocyte colony-stimulating factor (rHu GM-CSF). Seven days following treatment with daily subcutaneous injection of 270 μg rHu GM-CSF combined with antibiotics and glucocorticosteroids, granulocytes reappeared in the peripheral blood and the sepsis resolved. No side effects of the treatment were observed. The combination of rHu GM-CSF and glucocorticosteroids was successful in restoring normal granulocyte count.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalAdverse Drug Reactions and Toxicological Reviews
Volume15
Issue number2
Publication statusPublished - 1996

Fingerprint

Colony-Stimulating Factors
Granulocyte Colony-Stimulating Factor
Monocytes
Bone
Bone Marrow
Intercellular Signaling Peptides and Proteins
Granulocytes
Pharmaceutical Preparations
Methimazole
Antithyroid Agents
Chemotherapy
Agranulocytosis
Blood
Subcutaneous Injections
Therapeutics
Neutropenia
Bone Marrow Transplantation
Cells
Anti-Bacterial Agents
Sepsis

Keywords

  • Drug-induced agranulocytosis
  • Recombinant human GM-CSF
  • Thyrotoxicosis

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Treatment of drug-induced bone marrow suppression with recombinant human granulocyte/monocyte colony stimulating factor. / Somogyi, A.; Rosta, Andras; Láng, I.; Werling, Klara.

In: Adverse Drug Reactions and Toxicological Reviews, Vol. 15, No. 2, 1996, p. 119-124.

Research output: Contribution to journalArticle

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