Treatment of Community-Acquired Pneumonia in Adults: Analysis of the National Dispensing Database

Maria Matuz, Julia Bognar, Edit Hajdu, Peter Doro, Andrea Bor, Reka Viola, Gyongyver Soos, R. Benkó

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Crude national ambulatory antibiotic dispensing data (2007-2011) of adult patients (aged between 20 and below 65 years) with CAP were obtained and expressed as DDD per 1000 inhabitants and per day (DID). European quality indicators of antibiotic prescribing were calculated and adherence rate to the national CAP guideline was assessed. Antibiotic use for CAP in adults ranged between 0.27 and 0.30 DID in various years. The most frequently used antibacterials were levofloxacin, co-amoxiclav and clarithromycin. Antibiotic use in CAP was compliant with the European recommendations in 6.4% in 2007, which decreased to 4.9% by 2011, in contrast to the optimal compliant range of 80-100%. The consumption of fluoroquinolones mounted up to ~40% in both genders, which exceeded the recommended range (0-5%) substantially. National guideline also favoured the use of macrolides in the empiric therapy of CAP in otherwise healthy adults; hence, guideline-concordant antibiotic use ranged between 24.0-32.3%. Agents that were contra-indicated in the empiric therapy of CAP were also used in 6.5-9.0% in various years. These data reflect some worrisome figures and trends in the outpatient antibiotic treatment of adults with CAP. Clarified and updated national guidelines focusing on outpatients and incentives/regulations to increase guideline concordance are warranted.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalBasic and Clinical Pharmacology and Toxicology
Volume117
Issue number5
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Pneumonia
Databases
Anti-Bacterial Agents
Guidelines
Outpatients
Therapeutics
Dichlorodiphenyldichloroethane
Amoxicillin-Potassium Clavulanate Combination
Levofloxacin
Clarithromycin
Fluoroquinolones
Macrolides
Motivation

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Treatment of Community-Acquired Pneumonia in Adults : Analysis of the National Dispensing Database. / Matuz, Maria; Bognar, Julia; Hajdu, Edit; Doro, Peter; Bor, Andrea; Viola, Reka; Soos, Gyongyver; Benkó, R.

In: Basic and Clinical Pharmacology and Toxicology, Vol. 117, No. 5, 01.11.2015, p. 330-334.

Research output: Contribution to journalArticle

Matuz, Maria ; Bognar, Julia ; Hajdu, Edit ; Doro, Peter ; Bor, Andrea ; Viola, Reka ; Soos, Gyongyver ; Benkó, R. / Treatment of Community-Acquired Pneumonia in Adults : Analysis of the National Dispensing Database. In: Basic and Clinical Pharmacology and Toxicology. 2015 ; Vol. 117, No. 5. pp. 330-334.
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