Bipoláris betegek lamotrigin kezelése – Relapszus ráta és szuicid magatartás 6 hónapos követés során

Translated title of the contribution: Treatment of bipolar depression with lamotrigine – rate of relapse and suicidal behaviour during 6 month follow-up treatment

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present paper describes a 8-month prospective, observational, non-intervention multicentric study in 969 bipolar patients, where data were obtained on changes during lamotrigine treatment with special focus rates of relapse, suicidal behaviour and adverse events. 969 patients entered the study and 961 patients (99%) completed the study. Patients received lamotrigine mostly as an add-on treatment in addition to ongoing antidepressant and/or antipsychotic medication. By the end of the six-month treatment period 38% of patients achieved remission and rate of relapse after three months was 24%. Rate of adverse events was very low (1%) and they in no case led o termination of therapy. At baseline 17% of patients had clinically significant suicide risk which gradually decreased to 2.1% during the 6-month study period. No suicide attempt or completed suicide ook place during the study period. Results indicate that lamotrigine is an effective and well-tolerated treatment for the acute and long-term treatment of bipolar patients.

Original languageHungarian
Pages (from-to)7-13
Number of pages7
JournalNeuropsychopharmacologia Hungarica
Volume17
Issue number1
Publication statusPublished - 2015

Fingerprint

Bipolar Disorder
Recurrence
Suicide
Therapeutics
lamotrigine
Antidepressive Agents
Antipsychotic Agents

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

Cite this

@article{9a1612d4572f45e182272710870ed52c,
title = "Bipol{\'a}ris betegek lamotrigin kezel{\'e}se – Relapszus r{\'a}ta {\'e}s szuicid magatart{\'a}s 6 h{\'o}napos k{\"o}vet{\'e}s sor{\'a}n",
abstract = "The present paper describes a 8-month prospective, observational, non-intervention multicentric study in 969 bipolar patients, where data were obtained on changes during lamotrigine treatment with special focus rates of relapse, suicidal behaviour and adverse events. 969 patients entered the study and 961 patients (99{\%}) completed the study. Patients received lamotrigine mostly as an add-on treatment in addition to ongoing antidepressant and/or antipsychotic medication. By the end of the six-month treatment period 38{\%} of patients achieved remission and rate of relapse after three months was 24{\%}. Rate of adverse events was very low (1{\%}) and they in no case led o termination of therapy. At baseline 17{\%} of patients had clinically significant suicide risk which gradually decreased to 2.1{\%} during the 6-month study period. No suicide attempt or completed suicide ook place during the study period. Results indicate that lamotrigine is an effective and well-tolerated treatment for the acute and long-term treatment of bipolar patients.",
keywords = "Bipolar disorder, Lamotrigine, Relapse, Remission, Suicide risk",
author = "Z. R{\'i}hmer and X. Gonda and J. K{\'a}lm{\'a}n",
year = "2015",
language = "Hungarian",
volume = "17",
pages = "7--13",
journal = "Neuropsychopharmacologia Hungarica",
issn = "1419-8711",
publisher = "Hungarian Association of Psychopharmacology",
number = "1",

}

TY - JOUR

T1 - Bipoláris betegek lamotrigin kezelése – Relapszus ráta és szuicid magatartás 6 hónapos követés során

AU - Ríhmer, Z.

AU - Gonda, X.

AU - Kálmán, J.

PY - 2015

Y1 - 2015

N2 - The present paper describes a 8-month prospective, observational, non-intervention multicentric study in 969 bipolar patients, where data were obtained on changes during lamotrigine treatment with special focus rates of relapse, suicidal behaviour and adverse events. 969 patients entered the study and 961 patients (99%) completed the study. Patients received lamotrigine mostly as an add-on treatment in addition to ongoing antidepressant and/or antipsychotic medication. By the end of the six-month treatment period 38% of patients achieved remission and rate of relapse after three months was 24%. Rate of adverse events was very low (1%) and they in no case led o termination of therapy. At baseline 17% of patients had clinically significant suicide risk which gradually decreased to 2.1% during the 6-month study period. No suicide attempt or completed suicide ook place during the study period. Results indicate that lamotrigine is an effective and well-tolerated treatment for the acute and long-term treatment of bipolar patients.

AB - The present paper describes a 8-month prospective, observational, non-intervention multicentric study in 969 bipolar patients, where data were obtained on changes during lamotrigine treatment with special focus rates of relapse, suicidal behaviour and adverse events. 969 patients entered the study and 961 patients (99%) completed the study. Patients received lamotrigine mostly as an add-on treatment in addition to ongoing antidepressant and/or antipsychotic medication. By the end of the six-month treatment period 38% of patients achieved remission and rate of relapse after three months was 24%. Rate of adverse events was very low (1%) and they in no case led o termination of therapy. At baseline 17% of patients had clinically significant suicide risk which gradually decreased to 2.1% during the 6-month study period. No suicide attempt or completed suicide ook place during the study period. Results indicate that lamotrigine is an effective and well-tolerated treatment for the acute and long-term treatment of bipolar patients.

KW - Bipolar disorder

KW - Lamotrigine

KW - Relapse

KW - Remission

KW - Suicide risk

UR - http://www.scopus.com/inward/record.url?scp=84927611588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927611588&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 7

EP - 13

JO - Neuropsychopharmacologia Hungarica

JF - Neuropsychopharmacologia Hungarica

SN - 1419-8711

IS - 1

ER -