Treatment of alcoholic liver disease including emerging therapies, novel targets, and liver transplantation

Jan Petrasek, G. Szabó

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Therapies in alcoholic liver disease and alcoholic hepatitis have not evolved in decades. This is in striking contrast to the high mortality of patients with acute alcoholic hepatitis indicating an unmet medical need for more effective treatments. In addition to alcohol cessation and abstinence that are difficult to achieve for many patients, pharmacotherapy with corticosteroids remains to be the main standard of care in acute alcoholic hepatitis. In a subset of patients, pentoxifylline may provide some benefits, while most studies failed to prove obvious benefits. This chapter summarizes the recent literature on abstinence, nutrition, corticosteroids, and pentoxifylline that are all used in the general clinical practice. The challenges of liver transplantation in patients with alcoholic liver disease are also discussed. We provide a list of ongoing clinical trials and identify novel targets and approaches that may deserve investigation in alcoholic liver disease based on evidence from preclinical studies or state-of-the-art pathomechanistic understanding.

Original languageEnglish
Title of host publicationAlcoholic and Non-Alcoholic Fatty Liver Disease
Subtitle of host publicationBench to Bedside
PublisherSpringer International Publishing
Pages291-311
Number of pages21
ISBN (Electronic)9783319205380
ISBN (Print)9783319205373
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Abstinence
  • Alcoholic hepatitis
  • Corticosteroids
  • IL-1 receptor antagonist
  • Pentoxifylline
  • Zinc

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Petrasek, J., & Szabó, G. (2015). Treatment of alcoholic liver disease including emerging therapies, novel targets, and liver transplantation. In Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside (pp. 291-311). Springer International Publishing. https://doi.org/10.1007/978-3-319-20538-0_15