'Treat to Target' - Lessons Learnt

Zsuzsanna Kurti, Zsuzsanna Vegh, Petra Anna Golovics, P. Lakatos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Therapeutic management in inflammatory bowel diseases (IBD) has significantly changed in the last decades with the advent of biological therapy resulting in new treatment targets other than clinical symptoms. Key Messages: Patient stratification in the early stage of the disease is an important step to identify patients with poor prognosis, who might benefit from early aggressive treatment to avoid complications in the later disease course. Recent randomized and hypothesis driven (e.g., Randomized Evaluation of an Algorithm for Crohn's Treatment, Post-Operative Crohn's Endoscopic Recurrence) clinical trials conducted in the biological era underscore the need of objective disease monitoring including assessment of biomarkers (e.g., C-reactive protein and calprotectin), mucosal healing and, for biologically treated patients, therapeutic drug monitoring beside clinical symptom assessment in both Crohn's disease and ulcerative colitis. Conclusions: Assessing the treatment efficacy objectively has become an important element of patient monitoring besides clinical symptom assessment. Further clinical studies are needed to assess whether implementation of new therapeutic algorithms based on these targets and tight monitoring in clinical practice have the potential to further improve long-term disease outcomes in IBD.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalDigestive Diseases
Volume34
Issue number1-2
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Disease monitoring
  • Inflammatory bowel disease
  • Objective
  • Treat to target
  • Treatment strategy

ASJC Scopus subject areas

  • Gastroenterology

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    Kurti, Z., Vegh, Z., Golovics, P. A., & Lakatos, P. (2016). 'Treat to Target' - Lessons Learnt. Digestive Diseases, 34(1-2), 147-152. https://doi.org/10.1159/000443131